Journal
CLINICAL CANCER RESEARCH
Volume 28, Issue 10, Pages 1996-1998Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-22-0214
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Funding
- NIH/NCI [R01 CA238163]
- American Cancer Society [RSG-18-169-01]
- Cancer Research Institute Lloyd J. Old STAR Award
- Mark Foundation for Cancer Research Emerging Leader Award
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An objective approach was used to study the sentinel lymph node landscape in patients with stage I-III cutaneous melanoma, revealing that micrometastasis is associated with progressive immune dysfunction. Tumor-induced lymph node dysfunction may lead to new hypotheses for neoadjuvant therapy that aims to reinvigorate the body's own anti-tumor immunity.
An unbiased approach to map the sentinel lymph node landscape reveals progressive immune dysfunction associated with micrometastasis in patients with stage I-III cutaneous melanoma. Evidence of tumor-induced lymph node dysfunction may motivate new hypotheses for neoadjuvant therapy with potential to reinvigorate endogenous antitumor immunity.
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