Uric acid is associated with morpho-functional adipose tissue markers in apparently healthy subjects

Background: Studies have focused on the search of novel biomarkers that allow to easily identify dysfunctional adipose tissue (AT). Uric acid (UA) could be produced and reabsorbed by AT. It has been suggested that the increases of UA concentrations participates in AT dysfunction. We investigated the association of UA with morpho-functional adipose tissue markers in apparently healthy subjects. Methods: Forty apparently healthy individuals were included. Dietary habits and anthropometrical features were evaluated. Circulating concentrations of UA, adiponectin, leptin, and plasminogen activator inhibitor-1 (PAI-1) were quantified. Periumbilical subcutaneous AT samples were obtained and adipocyte number, adipocyte area, and macrophages content were assessed. Results: The present study included 40 healthy subjects (67% women) with an average age of 57 +/- 9 y, BMI of 26 +/- 4 (kg/m(2)). UA showed a significant association with the number and mean area of adipocytes, macrophages number, adiponectin, and PAI-1. Although UA was independently associated with the number and mean area of adipocytes, macrophages number, adiponectin into the adjusted multivariable model. Conclusion: UA concentrations are associated with morpho-functional adipose tissue markers. Our results underscore the importance of UA as one earlier instigator of adipose tissue dysfunction in subjects without metabolic abnormalities.

Automated summary

Results indicate that uric acid concentration is associated with dysfunctional adipose tissue. Despite the subjects being apparently healthy, the study demonstrates that uric acid is an early instigator of adipose tissue dysfunction.