4.3 Article

First live birth in China after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency

Journal

CLIMACTERIC
Volume 25, Issue 4, Pages 421-424

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/13697137.2022.2064215

Keywords

Ovarian tissue cryopreservation; transplantation; first; live birth; China; premature ovarian insufficiency

Funding

  1. Beijing Natural Science Foundation [7202047]
  2. Capital's Funds for Health Improvement and Research [20202-2112, 2016-2-2113]
  3. Beijing Hospitals Authority' Ascent Plan [DFL20181401]
  4. Beijing Municipal Science & Technology Commission [Z161100000516143]
  5. Beijing Hospitals Authority Clinical medicine Development [XMLX201710]

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This article reports the first live birth resulting from ovarian tissue cryopreservation and transplantation in China. It provides a new treatment option for premature ovarian insufficiency.
Objective This article reports the first live birth after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency in China. Methods A patient with myelodysplastic syndrome received ovarian tissue cryopreservation before hematopoietic stem cell transplantation, and six ovarian cortex strips were thawed and transplanted into her peritoneal pocket 2 years later. Results Pregnancy occurred spontaneously 27 months after grafting, and a healthy girl was born at 38 weeks gestation. Until now, the child has developed normally without any major diseases. Conclusions We report the first live birth resulting from ovarian tissue cryopreservation and transplantation in China.

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