Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii

Two sulfonated diterpenoid alkaloids possessing different but related novel carbon skeletons, named aconidenusulfonine A (1) and 12,16-secoaconidenusulfonine A (2), respectively, were isolated as minor components from an aqueous extract of the lateral roots of Aconitum carmichaelii (Fu Zi). The structures of 1 and 2, representing the first two C-21-diterpenoid alkaloids from nature, were determined by analysis of various spectroscopic data and chemical transformation, of which 1 was further proved by single-crystal X-ray diffraction. Especially, 1 exhibited dose-depended analgesic activity consistent with the clinical function of Fu Zi. (c) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

Two sulfonated diterpenoid alkaloids with novel carbon skeletons, named aconidenusulfonine A (1) and 12,16-secoaconidenusulfonine A (2), were isolated from the roots of Aconitum carmichaelii (Fu Zi). The structures of 1 and 2 were determined through spectroscopic analysis and chemical transformation, and the structure of 1 was further confirmed by single-crystal X-ray diffraction. Moreover, compound 1 exhibited dose-dependent analgesic activity.