4.7 Article

Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice

Related references

Note: Only part of the references are listed.
Article Engineering, Environmental

Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice

Baolian Hou et al.

Summary: This study evaluated the impact of microplastics on spermatogenesis in mice, showing a significant reduction in sperm count and an increase in deformity rate. Exposure to microplastics caused atrophy, shedding, and apoptosis of sperm cells in the testis, and disrupted the balance of Nrf2/HO-1/NF-κB pathway, leading to abnormal sperm quality in ICR mice.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Plasticenta: First evidence of microplastics in human placenta

Antonio Ragusa et al.

Summary: The study revealed the presence of microplastic fragments in human placentas, with different shapes and possible origins from man-made coatings, paints, adhesives, etc.

ENVIRONMENT INTERNATIONAL (2021)

Article Environmental Sciences

The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase-1 signaling pathway and oxidative stress in Wistar rats

Jialiu Wei et al.

Summary: The study revealed that exposure to microplastics can damage cardiac structure and function in Wistar rats, leading to oxidative stress, pyroptosis, apoptosis, and activation of inflammasomes in cardiac tissue. These findings suggest that pyroptosis plays a crucial role in microplastic-induced cardiotoxicity and may contribute to understanding the mechanisms of cardiac dysfunction caused by microplastics.

ENVIRONMENTAL TOXICOLOGY (2021)

Article Engineering, Environmental

Microplastic ingestion induces behavioral disorders in mice: A preliminary study on the trophic transfer effects via tadpoles and fish

Amanda Pereira da Costa Araujo et al.

Summary: This study confirmed that polyethylene microplastics can accumulate in animals, affect their behavior, and this impact can be passed on to higher trophic levels in the food chain, negatively impacting the survival of animals.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats

Junyu Hou et al.

Summary: The study showed that exposure to Polystyrene microplastics (PS MPs) could lead to a decrease in the number of growing follicles in rats' ovaries, as well as affecting the oxidative stress response in ovarian tissue. This could trigger pyroptosis and apoptosis of ovarian granulosa cells, potentially impacting female fertility. The findings provide new insights into the toxicity of microplastics on female reproduction.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Engineering, Environmental

Soil microplastic pollution in an e-waste dismantling zone of China

Bingwen Chai et al.

WASTE MANAGEMENT (2020)

Review Biochemistry & Molecular Biology

Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis

Hulya Bayir et al.

CELL CHEMICAL BIOLOGY (2020)

Article Engineering, Environmental

Toxicity-based toxicokinetic/toxicodynamic assessment for bioaccumulation of polystyrene microplastics in mice

Ying-Fei Yang et al.

JOURNAL OF HAZARDOUS MATERIALS (2019)

Review Biochemical Research Methods

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Giovanni C. Forcina et al.

PROTEOMICS (2019)

Editorial Material Oncology

ROS Promotes Cancer Cell Survival through Calcium Signaling

Colleen R. Reczek et al.

CANCER CELL (2018)

Article Environmental Sciences

Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice

Liang Lu et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

Article Cell Biology

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

Xianxian Wu et al.

CELL DEATH & DISEASE (2018)

Article Environmental Sciences

NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter

Runxiao Zheng et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2018)

Review Environmental Sciences

Microplastics in air: Are we breathing it in?

Johnny Gasperi et al.

CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH (2018)

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Ecology

Interactions of microplastic debris throughout the marine ecosystem

Tamara S. Galloway et al.

NATURE ECOLOGY & EVOLUTION (2017)

Article Multidisciplinary Sciences

Field evidence for transfer of plastic debris along a terrestrial food chain

Esperanza Huerta Lwanga et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure

Tammo Mueller et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

Review Biochemistry & Molecular Biology

Mechanisms of ferroptosis

Jennifer Yinuo Cao et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Article Engineering, Environmental

Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver

Yifeng Lu et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2016)

Review Biochemistry & Molecular Biology

Mechanism and Regulation of NLRP3 Inflammasome Activation

Yuan He et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Review Cell Biology

Ferrootosis: Death by Lipid Peroxidation

Wan Seok Yang et al.

TRENDS IN CELL BIOLOGY (2016)

Article Environmental Sciences

Pollutants bioavailability and toxicological risk from microplastics to marine mussels

Carlo Giacomo Avio et al.

ENVIRONMENTAL POLLUTION (2015)

Article Engineering, Environmental

Ingestion of Plastic Microfibers by the Crab Carcinus maenas and Its Effect on Food Consumption and Energy Balance

Andrew J. R. Watts et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2015)

Review Cell Biology

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

Roman Fischer et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

Review Biochemistry & Molecular Biology

The role of iron and reactive oxygen species in cell death

Scott J. Dixon et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Toxicology

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

Paul M. Peeters et al.

PARTICLE AND FIBRE TOXICOLOGY (2014)

Article Pathology

Change Trends of Organ Weight Background Data in Sprague Dawley Rats at Different Ages

Ying Piao et al.

JOURNAL OF TOXICOLOGIC PATHOLOGY (2013)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Review Immunology

Caspase-1-induced pyroptotic cell death

Edward A. Miao et al.

IMMUNOLOGICAL REVIEWS (2011)

Review Environmental Sciences

Microplastics in the marine environment

Anthony L. Andrady

MARINE POLLUTION BULLETIN (2011)

Article Environmental Sciences

Is marine debris ingestion still a problem for the coastal marine biota of southern Brazil?

Paula S. Tourinho et al.

MARINE POLLUTION BULLETIN (2010)

Review Multidisciplinary Sciences

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

Kate Schroder et al.

SCIENCE (2010)

Review Biochemistry & Molecular Biology

Regulation of glutathione synthesis

Shelly C. Lu

MOLECULAR ASPECTS OF MEDICINE (2009)

Article Environmental Sciences

Synthetic polymers in the marine environment: A rapidly increasing, long-term threat

Charles James Moore

ENVIRONMENTAL RESEARCH (2008)

Article Engineering, Environmental

Ingested microscopic plastic translocates to the circulatory system of the mussel, Mytilus edulis (L.)

Mark A. Browne et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2008)

Review Gastroenterology & Hepatology

AGA technical review on the evaluation of liver chemistry tests

RM Green et al.

GASTROENTEROLOGY (2002)