Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 17, Issue 15, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202200400
Keywords
organocatalysis; vinylogy; annulation; molecular diversity; heterocycles
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Funding
- IIT Madras
- DST-SERB, India [EMR/2014/000225]
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The cascade annulation between alkylidene malononitriles and cyclic sulfamidate imines was controlled under organocatalysis, allowing selective access to polycyclic and densely functionalized dihydropyridines and pyridines in high yields. The protocol is scalable and has a broad substrate scope, and the products were further utilized in the synthesis of tetracyclic pyridopyrimidines, demonstrating synthetic versatility.
The cascade annulation between alkylidene malononitriles and cyclic sulfamidate imines has been controlled by leveraging the sulfamate functionality under organocatalysis, which allows selective access to polycyclic and densely functionalized dihydropyridines and pyridines in high yields. The protocol is scalable and shows broad substrate scope. The products were also engaged in the preparation of tetracyclic pyridopyrimidines, showcasing the synthetic versatility.
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