Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 17, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202200142
Keywords
self-assembly; DNA structures; cleavage reaction; reduction
Categories
Funding
- Uehara Memorial Foundation
- JSPS
- Japan Society for the Promotion of Science [20K05563]
- Life Science Research Center, Gifu University
- iGCORE collaboration grant
- Grants-in-Aid for Scientific Research [20K05563] Funding Source: KAKEN
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In this study, a new reduction-cleavable spacer (RCS) based on a nitrobenzene scaffold was designed and synthesized for constructing reduction-responsive oligonucleotides using standard phosphoramidite chemistry. Furthermore, it was demonstrated that the introduction of the RCS in the middle of an oligonucleotide (30 nt) allowed for the construction of a self-assembled microsphere capable of exhibiting a reduction-responsive disassembly.
Here, we describe the design and synthesis of a new reduction-cleavable spacer (RCS) based on a nitrobenzene scaffold for constructing reduction-responsive oligonucleotides according to standard phosphoramidite chemistry. In addition, we demonstrate that the introduction of the RCS in the middle of an oligonucleotide (30 nt) enables the construction of a self-assembled microsphere capable of exhibiting a reduction-responsive disassembly.
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