4.6 Article

Dynamic Amino Acid Side-Chains Grafting on Folded Peptide Backbone

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Trends in peptide drug discovery

Markus Muttenthaler et al.

Summary: This Perspective summarizes key trends in peptide drug discovery and development, including human hormones, elegant medicinal chemistry and rational design strategies, peptide drugs derived from nature, and major breakthroughs in molecular biology and peptide chemistry. It also emphasizes lessons from earlier approaches that are still relevant today and discusses emerging strategies impact on peptide drug discovery.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Chemistry, Multidisciplinary

Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase

Ravindra P. Jumde et al.

Summary: Target-directed dynamic combinatorial chemistry (tdDCC) was used to identify and optimize ligands for the anti-infective target DXPS, resulting in acylhydrazone-based inhibitors. The tailored tdDCC runs provided insights into the structure-activity relationship of these novel inhibitors, with competition runs offering important information about their mode of inhibition. This approach has the potential to expedite drug-discovery and may be applicable to various biological targets.

CHEMICAL SCIENCE (2021)

Review Chemistry, Multidisciplinary

Peptidomimetic toolbox for drug discovery

Elena Lenci et al.

CHEMICAL SOCIETY REVIEWS (2020)

Review Chemistry, Multidisciplinary

Dynamic Combinatorial Chemistry: A New Methodology Comes of Age

Priska Frei et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

Article Chemistry, Organic

Generation of Dynamic Combinatorial Libraries Using Hydrazone-Functionalized Surface Mimetics

Sarah H. Hewitt et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2018)

Article Chemistry, Medicinal

Discovery of a Biologically Active Bromodomain Inhibitor by Target-Directed Dynamic Combinatorial Chemistry

Paula Garcia et al.

ACS MEDICINAL CHEMISTRY LETTERS (2018)

Article Chemistry, Multidisciplinary

Helix Propensities of Amino Acid Residues via Thioester Exchange

Brian F. Fisher et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Chemistry, Multidisciplinary

Target-directed Dynamic Combinatorial Chemistry: A Study on Potentials and Pitfalls as Exemplified on a Bacterial Target

Priska Frei et al.

CHEMISTRY-A EUROPEAN JOURNAL (2017)

Review Chemistry, Multidisciplinary

Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers

Yun Liu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

Article Chemistry, Multidisciplinary

An α-helical peptidomimetic scaffold for dynamic combinatorial library formation

Nathalie Busschaert et al.

CHEMICAL COMMUNICATIONS (2017)

Article Chemistry, Multidisciplinary

Dynamic Expression of DNA Complexation with Self-assembled Biomolecular Clusters

Eline Bartolami et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Biochemistry & Molecular Biology

Sequence Adaptive Peptide-Polysaccharide Nanostructures by Biocatalytic Self-Assembly

Yousef M. Abul-Haija et al.

BIOMACROMOLECULES (2015)

Article Chemistry, Multidisciplinary

Reversible Native Chemical Ligation: A Facile Access to Dynamic Covalent Peptides

Yves Ruff et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Chemistry, Multidisciplinary

A High-Resolution Structure that Provides Insight into Coiled-Coil Thiodepsipeptide Dynamic Chemistry

Zehavit Dadon et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Article Chemistry, Multidisciplinary

Bivalent Enzyme Inhibitors Discovered Using Dynamic Covalent Chemistry

Alexandra J. Clipson et al.

CHEMISTRY-A EUROPEAN JOURNAL (2012)

Article Chemistry, Multidisciplinary

Templating a polymer-scaffolded dynamic combinatorial library

Clare S. Mahon et al.

CHEMICAL COMMUNICATIONS (2011)

Review Biochemical Research Methods

Dynamic covalent chemistry in aid of peptide self-assembly

Jan W. Sadownik et al.

CURRENT OPINION IN BIOTECHNOLOGY (2010)

Article Chemistry, Medicinal

Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases

Gihane Nasr et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Article Chemistry, Organic

Selective Synthesis and Structural Elucidation of S-Acyl- and N-Acylcysteines

Alan R. Katritzky et al.

JOURNAL OF ORGANIC CHEMISTRY (2009)

Article Multidisciplinary Sciences

Self-Assembling Sequence-Adaptive Peptide Nucleic Acids

Yasuyuki Ura et al.

SCIENCE (2009)

Review Chemistry, Multidisciplinary

beta-Hairpin Peptidomimetics: Design, Structures and Biological Activities

John A. Robinson

ACCOUNTS OF CHEMICAL RESEARCH (2008)

Article Chemistry, Multidisciplinary

Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry

Anthony Bugaut et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

Article Chemistry, Multidisciplinary

Two-vial, LC-MS identification of ephedrine receptors from a solution-phase dynamic combinatorial library of over 9000 components

R. Frederick Ludlow et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Chemistry, Organic

Dynamic combinatorial chemistry: on the road to fulfilling the promise

Sylvain Ladame

ORGANIC & BIOMOLECULAR CHEMISTRY (2008)

Article Chemistry, Multidisciplinary

Amplification of bifunctional ligands for calmodulin from a dynamic combinatorial library

L Milanesi et al.

CHEMISTRY-A EUROPEAN JOURNAL (2006)

Article Chemistry, Multidisciplinary

Correlation between host-guest binding and host amplification in simulated dynamic combinatorial libraries

PT Corbett et al.

CHEMISTRY-A EUROPEAN JOURNAL (2004)

Article Chemistry, Multidisciplinary

Adaptive behavior of dynamic combinatorial libraries generated by assembly of different building blocks

Z Grote et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)