Installing Reduction Responsiveness into Biomolecules by Introducing Nitroaryl Groups

Artificially synthesized stimuli-responsive biomolecules are attractive as molecular tools for monitoring and modulating biological systems. In biological systems, redox stimuli are common, and their dysregulation is typically linked to various abnormal or disease states. In this Concept article, the molecular design of reduction-responsive biomolecules, such as peptides, nucleic acids, and saccharides, which are produced by introducing nitroaryl groups into them, is reviewed with a special emphasis on simple 4-nitrobenzene-based motifs.

Automated summary

Artificially synthesized stimuli-responsive biomolecules are attractive molecular tools for monitoring and modulating biological systems. This Concept article reviews the molecular design of reduction-responsive biomolecules, such as peptides, nucleic acids, and saccharides, produced by introducing nitroaryl groups into them, with a special emphasis on simple 4-nitrobenzene-based motifs.