TEMPO/PhI(OAc)2-mediated Direct Sulfoximination of Benzoxazoles under Metal-free Conditions

A metal-free reaction system consisting of TEMPO and PhI(OAc)(2) for the oxidative C-N coupling of benzoxazoles with NH-sulfoximines has been developed. The reaction can proceed under ambient atmosphere without any metal catalyst at room temperature to afford the corresponding 2-iminoazoles in moderate to high yields.

Automated summary

A metal-free reaction system utilizing TEMPO and PhI(OAc)(2) has been developed for the oxidative C-N coupling of benzoxazoles with NH-sulfoximines, resulting in moderate to high yields of corresponding 2-iminoazoles under ambient atmosphere without any metal catalyst at room temperature.