Chemical Constituents of the Roots of Schisandra chinensis

One new phenylpropanoid schineolignin D (1), one new sesquiterpene (-)-(7S,10S)-3,11,12,13-tetrahydroxycalamenene (2), one new quinic acid 4-(E)-O-coumaroylquinic acid ethyl ester (3), and seven known compounds 4-10 were separated from the roots of Schisandra chinensis. The chemical structures of all compounds were characterized by NMR spectroscopic experiments. All compounds were assessed for their neuroprotective effects on PC12 cell lines induced by H2O2. Compounds 1, 3-4, and 7 showed statistically significant neuroprotective activities with the negative control group at 12.5 mu M.

Automated summary

One new phenylpropanoid schineolignin D, one new sesquiterpene, one new quinic acid compound, and seven known compounds were isolated from the roots of Schisandra chinensis. NMR spectroscopic experiments confirmed the chemical structures of all compounds. Some of the compounds showed significant neuroprotective effects against H2O2-induced cell toxicity.