Hormesis and dental apical papilla stem cells

This paper provides an assessment of hormetic dose responses by stem cells of the apical papilla (SCAPs) from humans. Hormetic dose responses were induced in vitro by a broad range of agents, including dietary supplements (e.g., berberine, EGCG, resveratrol), pharmaceutical/commercial substances (e.g. fluoride, platelet rich plasma, lithium), and endogenous agents (e.g., insulin growth factor-2, transforming growth factor beta, lipopolysaccharide). This paper clarifies underlying mechanistic foundations of the SCAP-hormetic dose responses, the need for in vivo evaluation studies, and potential therapeutic implications of the present findings. Of particular significance is that approximately 90% of examples of hormetic effects reported with SCAPs occurred during the past two years, suggesting strong recent interest in their potential therapeutic applications.

Automated summary

This paper assesses the hormetic dose responses of stem cells from the apical papilla in humans and provides insights into their underlying mechanisms and potential therapeutic applications.