Recent Updates on Supramolecular-Based Drug Delivery - Macrocycles and Supramolecular Gels

Supramolecules-based drug delivery has attracted significant recent research attention as it could enhance drug solubility, retention time, targeting, and stimuli responsiveness. Among the different supramolecules and assemblies, the macrocycles and the supramolecular hydrogels are the two important categories investigated to a greater extent. Here, we provide the most recent advancements in these categories. Under macrocycles, reports on drug delivery by cyclodextrins, cucurbiturils, calixarenes/pillararenes, crown ethers and porphyrins are detailed. The second category discusses the supramolecular hydrogels of macrocycles/polymers and low molecular weight gelators. The updated information provided could be helpful to advance R & D in this vital area.

Automated summary

Supramolecules-based drug delivery has gained significant research attention for its potential to enhance drug properties. This article focuses on the recent advancements in two important categories: macrocycles and supramolecular hydrogels. Detailed reports on drug delivery using cyclodextrins, cucurbiturils, calixarenes/pillararenes, crown ethers, and porphyrins are provided under the macrocycles category. The second category discusses the supramolecular hydrogels of macrocycles/polymers and low molecular weight gelators. The updated information provided in this article could contribute to the advancement of research and development in this vital area.