4.6 Article

Simulations of liquid chromatography using two-dimensional non-equilibrium lumped kinetic model with bi-Langmuir isotherm

Journal

CHEMICAL ENGINEERING RESEARCH & DESIGN
Volume 181, Issue -, Pages 14-26

Publisher

ELSEVIER
DOI: 10.1016/j.cherd.2022.03.008

Keywords

Finite volume method; Two-dimensional lumped kinetic; model; Bi-Langmuir adsorption isotherm; Non-equilibrium transport; Mass transfer

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A two-dimensional non-equilibrium and non-linear lumped kinetic model of liquid chromatography is formulated and numerically approximated in this study to simulate the separation of multi-component mixtures in a packed fixed bed cylindrical column operating under isothermal conditions. By introducing distinct regions of injection at the column inlet, radial concentration gradients are generated to intensify the effect of mass transfer rate in the radial-direction. The developed numerical algorithm provides an efficacious mechanism for investigating the retention behavior, systematic monitoring, and efficient operation of non-equilibrium liquid chromatographic processes.
A two-dimensional non-equilibrium and non-linear lumped kinetic model of liquid chromatography is formulated and numerically approximated to simulate the separation of multi-component mixtures in a packed fixed bed cylindrical column operating under isothermal conditions. The model equations incorporate the bi-Langmuir adsorption thermo-dynamics as well as the radial and axial variations of concentration. By introducing distinct regions of injection at the column inlet, radial concentration gradients are generated to intensify the effect of mass transfer rate in the radial-direction, inside the column. The mathematical model is developed by a system of non-linear convection-diffusion partial differential equations for mass balance in the mobile phase, coupled with differential equation for mass balance in the stationary phase and algebraic equations for adsorption isotherm. In this study, a high-resolution, semi-discrete, finite-volume technique is formulated and applied to gain the numerical solution of the governing non-linear-model equations. A few numerical case studies are performed to investigate the effects of the various critical parameters on the process performance. The developed numerical algorithm provide an efficacious mechanism for investigating the retention behavior, systematic monitoring and efficient operation of non-equilibrium, liquid chromatographic processes. (c) 2022 Institution of Chemical Engineers. Published by Elsevier Ltd. All rights reserved.

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