4.7 Review

Upper critical solution temperature polymeric drug carriers

Journal

CHEMICAL ENGINEERING JOURNAL
Volume 432, Issue -, Pages -

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.134354

Keywords

Upper critical solution temperature; Drug carriers; Drug-loaded micelles; Drug-loaded surfaces; Drug-loaded gels

Funding

  1. National Natural Science Foundation of China [21704026, 22075087]
  2. Science and Technology Program of Guangzhou City [202002030229]
  3. Natural Science Foundation of Guangdong Province, China [2019A1515011129]
  4. Guangdong Basic and Applied Basic Research Foundation [2020A1515010986]
  5. Foundation for Xinghua Scholar of South China University of Technology

Ask authors/readers for more resources

Stimuli-responsive polymers are widely used as drug carriers in therapeutic applications. Upper critical solution temperature (UCST) polymeric carriers undergo a phase transition from hydrophobic to hydrophilic under the stimuli of temperature, near-infrared light, microwave, etc., thereby achieving a much more complete drug release. UCST polymeric carriers have recently emerged great potentials for controlled drug release, such as UCST polymeric micelles and hydrogels for cancer treatments and UCST polymeric surfaces for wound treatments, etc.. In this review, we mainly focus on UCST polymeric drug carriers based on different forms in recent five years.
Stimuli-responsive polymers are widely used as drug carriers in therapeutic applications. Upper critical solution temperature (UCST) polymeric carriers undergo a phase transition from hydrophobic to hydrophilic under the stimuli of temperature, near-infrared light, microwave, etc., thereby achieving a much more complete drug release. UCST polymeric carriers have recently emerged great potentials for controlled drug release, such as UCST polymeric micelles and hydrogels for cancer treatments and UCST polymeric surfaces for wound treatments, etc.. In this review, we mainly focus on UCST polymeric drug carriers based on different forms in recent five years. Various UCST polymers are first summarized based on their different structures. Drug-loaded UCST polymeric micelles with different stimuli, including with or without photothermal agents, pH-responsive and self-monitoring polymeric micelles, and representative drug-loaded UCST polymeric surfaces, including UCST polymeric coatings and mesoporous silica with UCST polymeric gate, are introduced. Finally, drug-loaded UCST polymeric hydrogels are also discussed. This review aims to draw attention to the advantages of UCST polymeric drug carriers and promote their clinical practice.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available