Journal
CHEMICAL ENGINEERING JOURNAL
Volume 431, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.133969
Keywords
Etoposide; Anticancer drug; Degradation; Photocatalysis; Transformation products; Toxicity
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This study investigated the degradation of the antineoplastic drug etoposide under UV irradiation. Photocatalytic degradation was found to be effective, especially at pH 4. Various transformation products were identified using mass spectrometry and prediction models, and some of these products were found to be potentially toxic.
This study presents the photolytic and photocatalytic degradation of antineoplastic drug etoposide (ETO) in aqueous solutions under UV irradiation. Photolytic degradation of ETO was slow with insufficient mineralization. The quantum yield of ETO's photolytic degradation was calculated and ranged from 0.00029 to 0.00273 mol Einstein-1. Photocatalytic degradation was proven effective, especially at pH 4, where k(obs) reached 0.963 min(-1). Overall, 29 TPs of photocatalysis were detected at pH 4 and 7. Structures were proposed for 23 of them, based on complementary use of low -/high-resolution MS and Quantitative Structure-Retention Relationship (QSRR) prediction models. The main proposed transformations were: addition and/or demethylation of hydroxyl groups, cyclization, dehydrogenation, full or partial deprotection of diols and the loss of sugar or 2,6-dimethoxyphenol moiety. Mineralization did not follow ETO's degradation. Toxicity assessment using Vibrio fischeri bioassay and in silico prediction model revealed the formation of partially recalcitrant and possibly toxic TPs.
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