Journal
CHEMCATCHEM
Volume 14, Issue 13, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.202200140
Keywords
Molnupiravir; (chemo)enzymatic processes; eco-friendly; industrial scale-up
Categories
Funding
- Spanish Ministry of Science and Innovation [PID2020-117025RB-I00]
- Santander Foundation [XSAN192006]
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This paper reviews the important milestones in the enzyme-mediated synthesis of Molnupiravir, discusses the advantages and drawbacks of different synthetic routes, and proposes new greener processes for Molnupiravir manufacturing.
Molnupiravir (Lagevrio (R)) is an orally-administered anti-COVID-19 agent. Due to the urgency to meet the worldwide demand and the growing environmental concern, there is a need for speed in the industrial implementation of novel and efficient bioprocesses for Molnupiravir synthesis. This concept paper aims to review the most relevant milestones that have guided important developments in the enzyme-mediated synthesis of Molnupiravir, including detailed comments on the advantages and drawbacks of the different synthetic routes. Finally, based on a personal perspective, new greener processes for Molnupiravir manufacturing are proposed and discussed.
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