4.6 Article

KLF2 mediates the suppressive effect of BDNF on diabetic intimal calcification by inhibiting HK1 induced endothelial-to-mesenchymal transition

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Endothelial cellmetabolicmemory causes cardiovascular dysfunction in diabetes

Yufeng Yao et al.

Summary: This study aimed to identify the molecular mechanism for hyperglycemia-induced metabolic memory in endothelial cells (ECs) and to demonstrate its critical importance in the development of cardiovascular dysfunction in diabetes. The results showed that hyperglycemia leads to dysregulation of multiple signaling pathways in ECs, which are remembered by the cells even under low glucose conditions and contribute to the development of cardiovascular disease. The study also identified a novel signaling pathway involved in metabolic memory.

CARDIOVASCULAR RESEARCH (2022)

Review Chemistry, Multidisciplinary

The glycolytic process in endothelial cells and its implications

Susan Wai Sum Leung et al.

Summary: Endothelial cells play a crucial role in regulating vascular tone and maintaining homeostasis. Cell metabolism, especially glycolysis, is essential for cell function and response to stimuli. Discussions on the role of glycolysis in cardiovascular disease may provide insights for future therapeutic strategies.

ACTA PHARMACOLOGICA SINICA (2022)

Article Cell Biology

BDNF corrects NLRP3 inflammasome-induced pyroptosis and glucose metabolism reprogramming through KLF2/HK1 pathway in vascular endothelial cells

Hong Jin et al.

Summary: The study indicates that BDNF inhibits ox-LDL induced NLRP3 inflammasome formation and pyroptosis in HUVECs through the KLF2/HK1-mediated modulation of glucose metabolism and preservation of mitochondrial homeostasis.

CELLULAR SIGNALLING (2021)

Article Biochemistry & Molecular Biology

Small extracellular vesicle-mediated Hsp70 intercellular delivery enhances breast cancer adriamycin resistance

Weizi Hu et al.

Summary: The study revealed that small extracellular vesicles (sEVs) mediated Hsp70 transfer enhances Adriamycin (ADR) resistance, mainly by reprogramming the recipient cell energy metabolism.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Endocrinology & Metabolism

Mitochondria Homeostasis and Vascular Medial Calcification

Min Li et al.

Summary: Vascular calcification is highly prevalent and predicts adverse cardiovascular events. The pathogenesis of calcification is complex and incompletely characterized, with evidence showing that mitochondrial dysfunction may play a key role in vascular smooth muscle cells calcification. Metabolic regulation could be a potential therapeutic target in vascular calcification.

CALCIFIED TISSUE INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to-mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells

Jian-An Pan et al.

Summary: The study revealed the protective role of irisin in EndMT and perivascular fibrosis in the cardiac microenvironment in a mouse DIC model, potentially reversing ROS accumulation and autophagy disorders by regulating UCP2. Irisin was found to be mainly secreted by cardiomyocytes and had a paracrine protective effect on endothelial cells. This study provides a novel perspective on the pathogenesis and potential treatment of DIC.

REDOX BIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Wnt2 Contributes to the Development of Atherosclerosis

Jinyu Zhang et al.

Summary: The study demonstrates that TGF-beta activates the endothelial-to-mesenchymal transition in human aortic endothelial cells, dependent on the Wnt signaling pathway. Wnt2 signaling is required for TGF-beta-mediated EndMT, and high levels of Wnt2 protein in atherosclerotic lesions confirm its involvement in atherosclerosis in vivo. This suggests that Wnt2 may contribute to atherosclerotic plaque development and could be a potential therapeutic target for controlling atherosclerosis.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Multidisciplinary Sciences

Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys

Swayam Prakash Sriyastava et al.

Summary: Endothelial SIRT3 regulates defective metabolism and fibrogenic pathways in diabetic kidneys, with its loss exacerbating fibrosis levels. SIRT3 deficiency in endothelial cells stimulates mesenchymal transformations in renal tubular epithelial cells.

ISCIENCE (2021)

Article Cardiac & Cardiovascular Systems

Periostin promotes arterial calcification through PPARγ-related glucose metabolism reprogramming

Yi Zhu et al.

Summary: This study found that periostin promoted arterial calcification, overactivated glycolysis, and disrupted OXPHOS in vascular smooth muscle cells. PPAR gamma agonists alleviated periostin-induced arterial calcification and corrected abnormal glycolysis and unbalanced mitochondrial homeostasis. The study also revealed a relationship between periostin and lactate levels in patients with coronary artery calcification.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling

Juan Huang et al.

Summary: The study indicates that blood flow plays a crucial role in vascular calcification, with calcification more likely to occur in branched areas. KLF2 inhibits vascular calcification by regulating endothelial BMP/SMAD1/5 signaling pathway.

CIRCULATION RESEARCH (2021)

Review Endocrinology & Metabolism

The Role of HIF1α-PFKFB3 Pathway in Diabetic Retinopathy

Jie Min et al.

Summary: Diabetic retinopathy is the leading cause of blindness in developed countries, with neuronal impairment often preceding microvascular abnormalities. Current therapeutic strategies fail to target neuronal deterioration, necessitating new approaches to address both vascular and neuronal impairment. The HIF1α-PFKFB3 signaling pathway plays a critical role in neurodegeneration and pathologic angiogenesis in DR, highlighting its potential as a metabolic intervention point.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Cell Biology

High Intakes of Bioavailable Phosphate May Promote Systemic Oxidative Stress and Vascular Calcification by Boosting Mitochondrial Membrane Potential-Is Good Magnesium Status an Antidote?

Mark F. McCarty et al.

Summary: Chronic kidney disease is associated with a significantly increased risk of cardiovascular mortality, vascular calcification, ventricular hypertrophy, and systemic oxidative stress. The elevated levels of hyperphosphatemia and fibroblast growth factor 23 (FGF23) are considered key factors in mediating this risk. These factors can lead to cardiac hypertrophy and oxidative stress, as well as impact mitochondrial function and NADPH oxidase complexes in vascular endothelium. Magnesium has been proposed as a protective factor against the effects of hyperphosphatemia, potentially due to its ability to counteract the increase in mitochondrial membrane potential caused by elevated phosphate levels.

CELLS (2021)

Article Medicine, Research & Experimental

A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis

Jian-Kui Du et al.

Summary: The study reveals the role of KLK8 in diabetic cardiomyopathy, with KLK8 deficiency attenuating cardiac fibrosis while KLK8 overexpression inducing EndMT. This provides a new direction for therapeutic strategies for diabetic cardiomyopathy.

THERANOSTICS (2021)

Article Hematology

Brain-Derived Neurotrophic Factor, a New Predictor of Coronary Artery Calcification

Hong Jin et al.

Summary: The study shows that plasma BDNF levels are associated with the Agatston score and can predict the occurrence of CAC. Age, hypertension, BDNF, and MGP were found to be independent predictors of CAC. Plasma BDNF and MGP levels were correlated with the Agatston score even after adjusting for other factors.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2021)

Review Endocrinology & Metabolism

The Role of HIF1 alpha-PFKFB3 Pathway in Diabetic Retinopathy

Jie Min et al.

Summary: Diabetic retinopathy (DR) is the leading cause of blindness for adults in developed countries, with microvasculopathy and neurodegeneration implicated in its development. Current therapeutic strategies mainly target the advanced stages and fail to address neuronal deterioration, highlighting the potential need for new approaches. The HIF1 alpha-PFKFB3 signaling pathway is identified as a key component across multiple cell types in the retina in both early and late stages of DR, suggesting its potential as a therapeutic target.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Hematology

Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis

Gangqi Wang et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Macrophage galectin-3 enhances intimal translocation of vascular calcification in diabetes mellitus

Zhen Sun et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

Review Endocrinology & Metabolism

The role of bone morphogenetic protein signaling in vascular calcification

Peiran Yang et al.

Review Biochemistry & Molecular Biology

The Vicious Cycle of Arterial Stiffness and Arterial Media Calcification

Geoffrey Van den Bergh et al.

TRENDS IN MOLECULAR MEDICINE (2019)

Article Biochemistry & Molecular Biology

BDNF release and signaling are required for the antidepressant actions of GLYX-13

T. Kato et al.

MOLECULAR PSYCHIATRY (2018)

Review Cell Biology

Endothelial Cell Metabolism in Health and Disease

Katerina Rohlenova et al.

TRENDS IN CELL BIOLOGY (2018)

Article Medicine, General & Internal

Arterial ageing: from endothelial dysfunction to vascular calcification

M. Tesauro et al.

JOURNAL OF INTERNAL MEDICINE (2017)

Article Hematology

Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3

Anuradha Doddaballapur et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

Katrien De Bock et al.

Article Hematology

KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells

Joost O. Fledderus et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)