Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 79, Issue 3, Pages -Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-022-04208-2
Keywords
Cranial neural crest cell; Osteoblast differentiation; Calvarial bone development; Gene regulatory network; Genetic mouse model; Birth defect
Categories
Funding
- Zhejiang Qianjiang Talent Program [21040040-E, 18042290-Y, 2021Q031]
- Department of Sci-Tech of Zhejiang Province [LGF19H140002]
- National Natural Science Foundation of China [81400489]
- Jiaxing Science TechnologyFoundation [2020AY10001]
Ask authors/readers for more resources
This article summarizes the important role of the cranial neural crest (CNC) in calvarial bone development, including discussing the potential cell fate of CNC and the gene regulatory network that controls this potential. Furthermore, the study has found a close correlation between CNC patterning disorders and clinical birth defects and diseases. The article emphasizes the potential regenerative alternative based on CNC patterning and genetic molecules for treating clinical disorders.
Calvarial bone is one of the most complex sequences of developmental events in embryology, featuring a uniquely transient, pluripotent stem cell-like population known as the cranial neural crest (CNC). The skull is formed through intramembranous ossification with distinct tissue lineages (e.g. neural crest derived frontal bone and mesoderm derived parietal bone). Due to CNC's vast cell fate potential, in response to a series of inductive secreted cues including BMP/TGF-beta, Wnt, FGF, Notch, Hedgehog, Hippo and PDGF signaling, CNC enables generations of a diverse spectrum of differentiated cell types in vivo such as osteoblasts and chondrocytes at the craniofacial level. In recent years, since the studies from a genetic mouse model and single-cell sequencing, new discoveries are uncovered upon CNC patterning, differentiation, and the contribution to the development of cranial bones. In this review, we summarized the differences upon the potential gene regulatory network to regulate CNC derived osteogenic potential in mouse and human, and highlighted specific functions of genetic molecules from multiple signaling pathways and the crosstalk, transcription factors and epigenetic factors in orchestrating CNC commitment and differentiation into osteogenic mesenchyme and bone formation. Disorders in gene regulatory network in CNC patterning indicate highly close relevance to clinical birth defects and diseases, providing valuable transgenic mouse models for subsequent discoveries in delineating the underlying molecular mechanisms. We also emphasized the potential regenerative alternative through scientific discoveries from CNC patterning and genetic molecules in interfering with or alleviating clinical disorders or diseases, which will be beneficial for the molecular targets to be integrated for novel therapeutic strategies in the clinic.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available