Journal
CELL STEM CELL
Volume 29, Issue 6, Pages 882-904Publisher
CELL PRESS
DOI: 10.1016/j.stem.2022.05.006
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Funding
- NIH [R35 HL155672, R01 HL136333, R01 HL134880, R01 AI141716, R01 HL136333S, R01 AG067584, R01 AG066544, R01 DK119394]
- Adrienne Malvin Helis Medical Research Foundation
- Cleo Meador and George Ryland Scott Endowed Chair in Hematology
- Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research [F31Diversity-1F31HL156500]
- American Society of Hematology Minority Hematology Graduate Student Fellowship
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Clonal hematopoiesis of indeterminate potential (CHIP) refers to the expansion of genetically variant hematopoietic cells, which increases with age and is associated with environmental factors such as infections, chemotherapy, and smoking. Understanding how these environmental contexts alter tissue microenvironments to facilitate the selection and expansion of specific CHIP mutant clones, as well as identifying remaining gaps in knowledge, will have implications for transplant and preventive medicine.
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially with age and is associated with increased risks of cancers, cardiovascular disease, and other maladies. Here, we discuss how environmental contexts associ-ated with CHIP, such as old age, infections, chemotherapy, or cigarette smoking, alter tissue microenviron-ments to facilitate the selection and expansion of specific CHIP mutant clones. Further, we consider major remaining gaps in knowledge, including intrinsic effects, clone size thresholds, and factors affecting clonal competition, that will determine future application of this field in transplant and preventive medicine.
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