Journal
CELL METABOLISM
Volume 34, Issue 6, Pages 836-+Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2022.04.011
Keywords
-
Categories
Funding
- US National Institute on Aging
Ask authors/readers for more resources
This study conducted comparative transcriptomics on 26 species with diverse lifespans and identified genes with expression levels correlated with maximum lifespan. The study found that genes involved in energy metabolism and inflammation are negatively correlated with lifespan, while genes involved in DNA repair, microtubule organization, and RNA transport are positively correlated. The study also uncovered circadian and pluripotency networks as central regulators of longevity.
Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with expression levels negatively or positively correlated with a species??? maximum lifespan (Neg-or Pos-MLS genes). Neg-MLS genes are primarily involved in energy metabolism and inflammation. Pos-MLS genes show enrichment in DNA repair, microtubule organization, and RNA transport. Expression of Neg-and Pos-MLS genes is modulated by interventions, including mTOR and PI3K inhibition. Regulatory networks analysis showed that Neg-MLS genes are under circadian regulation possibly to avoid persistent high expression, whereas Pos-MLS genes are targets of master pluripotency regulators OCT4 and NANOG and are upregulated during somatic cell reprogramming. Pos-MLS genes are highly expressed during embryogenesis but significantly downregulated after birth. This work provides targets for anti-aging interventions by defining pathways correlating with longevity across mammals and uncovering circadian and pluripotency networks as central regulators of longevity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available