Ketones regulate endothelial homeostasis

Article Medicine, Research & Experimental

Ketone body oxidation increases cardiac endothelial cell proliferation

Eva-Maria Weis et al.

Summary: Recent studies have shown that cardiac endothelial cells can oxidize ketone bodies to enhance cell proliferation, migration, and vessel sprouting. A high-fat, low-carbohydrate ketogenic diet can increase endothelial cell proliferation in mouse hearts and prevent blood vessel rarefication in a mouse model of heart hypertrophy.

EMBO MOLECULAR MEDICINE (2022)

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Article Medicine, Research & Experimental

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Gladys Ferrere et al.

Summary: Limited experimental evidence suggests a link between nutrition and cancer immunosurveillance. This study demonstrates that ketogenic diet induces an anti-tumor effect through 3HB-mediated T cell-mediated cancer immunosurveillance. 3HB prevents immune checkpoint inhibition and promotes the expansion of specific T cells, while KD also leads to compositional changes in gut microbiota.

JCI INSIGHT (2021)

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Review Biochemistry & Molecular Biology

3-Hydroxybutyrate as a Metabolite and a Signal Molecule Regulating Processes of Living Organisms

Justyna Mierziak et al.

Summary: 3-hydroxybutyrate is a crucial metabolite found in animals, microorganisms, and plants. It serves as an energy source in animals, a substrate for polyhydroxybutyrate synthesis in microorganisms, and a regulatory molecule influencing gene expression and DNA methylation levels in plants. Additionally, 3-HB plays vital roles in gene regulation, lipid metabolism, neuronal function, and epigenetic regulation in animals.

BIOMOLECULES (2021)

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Article Medicine, Research & Experimental