Overcoming drug resistance, the natural way

Colistin is an antibiotic of last resort for treating Gram-negative bacterial infections, but resistance is spreading rapidly. In a recent issue of Nature, Wang et al. use genome mining to identify and synthesize a natural variant that bypasses colistin resistance and offers new hope for tackling antimicrobial resistance.

Automated summary

Colistin, an antibiotic used as a last resort for treating Gram-negative bacterial infections, is facing rapid resistance. However, a recent study published in Nature discovered and synthesized a natural variant that can bypass colistin resistance, offering new hope in the fight against antimicrobial resistance.