Journal
CELL CYCLE
Volume 21, Issue 17, Pages 1856-1866Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2022.2074624
Keywords
Oral squamous cell carcinomas; lncRNA TUG1; miR-593-3p; MAPK
Categories
Funding
- Project of Wuhan University [2042022kf1214]
Ask authors/readers for more resources
This study demonstrated the significant roles of lncRNA TUG1, miR-593-3p, and MAPK signaling pathway in oral squamous cell carcinoma (OSCC). The findings suggest that targeting the TUG1/miR-593-3p/MAPK axis can potentially identify diagnostic biomarkers and therapies for OSCC.
Dysregulation of non-coding RNAs (ncRNAs) has been proved to play important roles in oral squamous cell carcinoma (OSCC). This study aimed to determine the combined role of lncRNA TUG1, miR-593-3p, and MAPK signaling in oral squamous cell carcinoma (OSCC) development. Here, we found that TUG1 was up-regulated in OSCC tissues and cell lines. Silencing TUG1 suppressed proliferation migration, invasion and promoted apoptosis of OSCC cells. We also validated that knockdown of TUG1 suppressed MAPK signaling pathway and inhibited EMT process in OSCC cells. Then, a novel LncRNA TUG1/ miR-593-3p/MAPK axis was verified to rescue cell viability in OSCC cells. Mechanistically, miR-593-3p bound to lncRNA TUG1, and lncRNA TUG1 positively regulated MAPK related proteins through acting as RNA sponger for miR-593-3p. Further gain- and loss-of-function experiments evidenced that the protective effects of lncRNA TUG1 knock-down on OSCC cells were abrogated by silencing miRNA-593-3p. The OSCC nude mice model experiments demonstrated that depletion of TUG1 further inhibited tumor growth. In conclusion, appropriate diagnostic biomarkers and therapies for OSCC can be identified by targeting the TUG1/miR-593-3p/MAPK axis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available