Journal
CELL CYCLE
Volume 21, Issue 18, Pages 1897-1914Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2022.2079054
Keywords
endothelial cell; ferroptosis; endothelial cell dysfunction; ROS; iron
Categories
Funding
- Natural Science Foundation of Jiangsu Province [BK20181227]
- Six talent peaks project in Jiangsu Province [WSN-126]
- Social Development Foundation of Jiangsu [BE2021694]
- Foundation of Health and Family Planning Commission of Jiangsu [H201644]
- Natural Science Foundation of China [81971817]
- Cardiovascular Disease Clinical Research Center of Zhenjiang [SS2018008]
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This study reviews recent findings to elucidate the role of ferroptosis in endothelial cells under different pathophysiologic settings.
Ferroptosis is a form of iron-dependent cell death caused by an excessive accumulation of reactive oxygen species and lipid peroxidation. The importance of ferroptosis in the occurrence and progression of various diseases is gradually being recognized; however, the exact biological effects and potential mechanisms of endothelial cell ferroptosis remain unclear. The endothelium forms the innermost layer of the blood vessels and lymphatic vessels. It acts as an important functional interface, responds to various pathological stimuli and causes endothelial dysfunction. Here, we review recent findings to elucidate the role of ferroptosis in endothelial cells under different pathophysiologic settings.
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