Journal
CARBOHYDRATE RESEARCH
Volume 515, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2022.108559
Keywords
Click chemistry; FimH; Hemagglutination; Mannoconjugate; Urinary tract infection
Funding
- Jordan University of Science and Technology (Jordan)
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In this study, two families (A, B) of mannose-triazole conjugates were synthesized by Cu(I) catalyzed azide-alkyne cycloaddition reaction. Family A exhibited higher activity compared to family B in a hemagglutination inhibition assay. The representative ligand 7a showed the highest inhibitory activity against FimH fimbrial lectin.
Two families (A, B) of triazole conjugates derived from D-mannose possessing reversed linkage functionality were easily assembled by Cu(I) catalyzed azide-alkyne cycloaddition reaction (CuAAC). The mannose precursors were built with either 3-azidopropyl or propargyl aglycones whereas the phenyl moieties were built with terminal azide or propargyl groups, respectively. In a hemagglutination inhibition (HAI) assay, family A (7a -11a), where the linker between the mannose residue and the triazole ring is three carbons displayed a 3-5 fold enhancement in activity compared to family B (13a -17a) having methyl-triazolyl moiety. The representative ligand 7a, where the terminal phenyl ring is substituted with an ester group and Cl atom exhibited the highest inhibitory activity with an HAI titer of 8 mu M. This compound could be a good candidate for the further design of potent mannosyl ligands targeting FimH fimbrial lectin.
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