Journal
CARBOHYDRATE POLYMERS
Volume 286, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119319
Keywords
Chitosan; Hemostasis; Gauze; Catechol; Wettability
Categories
Funding
- Social Development of Instructive Program of Fujian Province [2020Y0020]
- Natural Science Foundation of China [22175037, 52103108]
- Key Project for Advancing Science and Technology of Fujian Province [[2021] 415-2021G02005]
- Program for Innovative Research Team in Science and Technology in Fujian Province University
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A novel chitosan-catechol hemostatic gauze with impressive hemostatic performance on rat injuries has been developed through surface modification, demonstrating biodegradability and non-cytotoxicity while integrating three structure and function effects.
Development of efficient hemostatic gauze is critical to increasing survival rate by quick bleeding control of life-threatening hemorrhage. Herein, a novel chitosan non-woven hemostatic gauze is made by slightly surface modification with a special catechol compound, i.e. 3-(9,11,13-pentadecatrienyl)-1,2-benzenediol with a long side hydrophobic alkyl chain. Its wettability, interaction with red blood cell and platelet, and hemostatic efficacy on rat injuries are evaluated. This chitosan-catechol gauze demonstrates impressive hemostatic performances on rat femoral artery and liver laceration injury models (blood loss of this modified chitosan gauze is less than 17% of that of pristine chitosan gauze). Additionally, it is biodegradable, and maintains non-cytotoxicity. It integrates three structure and function effects together, i.e., anchoring effect between catechol and tissue, blood repelling effect from hydrophobic alkyl chain, and blood wicking effect from hydrophilic chitosan. Therefore, a new hemostatic mechanism is proposed for the excellent hemostatic potentials of this chitosan gauze.
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