Journal
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Volume 72, Issue 1, Pages 114-118Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0000000000000937
Keywords
HIV; trimethylamine-N-oxide; coronary artery disease
Categories
Funding
- NHLBI [RO1 HL095129]
- NIAID [P30AI094189]
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Cancer Institute (NCI)
- JHU CTSA [UL1 TR 001079]
- Esperion
- Procter Gamble
- Abbott
- Astra Zeneca
- Cleveland Heart Lab
- Pfizer Inc.
- Roche
- Takeda
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Recent evidence has shown a complex relationship between the gut microbiota, dietary nutrients, and cardiovascular disease (CVD). Trimethylamine-N-oxide (TMAO) production, initiated by the microbiota, has been associated with CVD events. We sought to test if this association exists in HIV-infected persons. After adjusting for aspirin use and CVD risk factors, HIV-infected men were more likely to have coronary stenosis in the second and third TMAO quartiles compared with the first quartile, but did not differ significantly in the fourth quartile. We found an inverted U-shaped association between TMAO levels and the presence of coronary artery stenosis among HIV-infected men.
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