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The effect of the polycystic ovary syndrome and hypothyroidism on the risk of fibrocystic breast changes: a meta-analysis

Journal

CANCER CELL INTERNATIONAL
Volume 22, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s12935-022-02547-5

Keywords

Polycystic ovary syndrome; Hypothyroidism; Fibrocystic change; Fibrocystic breast disease; Meta-analysis

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This study conducted a meta-analysis to investigate the association between polycystic ovary syndrome (PCOS), hypothyroidism, and fibrocystic breast changes. The results showed that women with PCOS were at a higher risk of developing fibrocystic breast changes.
This meta-analysis aimed to determine the pooled association between polycystic ovary syndrome (PCOS), hypothyroidism, and fibrocystic breast changes. We searched important databases, including PubMed (Medline), Scopus, Web of Science, and Embase to retrieve all relevant studies published from 1990 to April 2021. The bias risk of selected articles was assessed based on the JBI checklist. Our search strategy yielded a total of 487 articles from the international databases. After screening their full-texts, 6 articles met the inclusion criteria and were considered for meta-analysis. The effect of PCOS on the incidence of fibrocystic breast changes was 2.49 (95% CI 1.85-3.34). Also, the effect of hypothyroidism on the incidence of fibrocystic breast changes was 1.90 (95% CI 0.92-3.93). The results showed that women with PCOS were at higher risks to develop fibrocystic breast changes.

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