4.7 Review

A systematic review of the therapeutic effects of resveratrol in combination with 5-fluorouracil during colorectal cancer treatment: with a special focus on the oxidant, apoptotic, and anti-inflammatory activities

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

The cardioprotective effects of nano-curcumin against doxorubicin-induced cardiotoxicity: A systematic review

Hossein Moutabian et al.

Summary: Nano-curcumin can alleviate doxorubicin-induced cardiotoxicity and improve treatment efficacy.

BIOFACTORS (2022)

Article Oncology

Glycoprotein M6A Suppresses Lung Adenocarcinoma Progression via Inhibition of the PI3K/AKT Pathway

Qian Zhang et al.

Summary: This study revealed that GPM6A plays a suppressive role in the progression of lung adenocarcinoma, by inhibiting the PI3K/AKT pathway. This finding suggests that GPM6A could be a potential target for lung cancer therapy.

JOURNAL OF ONCOLOGY (2022)

Review Oncology

Resveratrol as an Enhancer of Apoptosis in Cancer: A Mechanistic Review

Milad Ashrafizadeh et al.

Summary: The resistance of cancer cells to therapy is a challenge, but drugs that modulate the apoptosis pathway, such as resveratrol, can enhance treatment efficacy.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress

Christophe Olivier et al.

Summary: GBM is a common primary brain tumor with poor prognosis, driven by GSCs in specialized microenvironments and characterized by resistance to therapy. ROS play a dual role in controlling cellular stability, affecting cell cycle, progression, and drug resistance in GBM, while also inducing cell death programs like apoptosis and autophagy. The metabolic adaptation and stromal components in the microenvironment contribute to oxidative stress and drug resistance in GBM progression.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Review Biochemistry & Molecular Biology

Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives

Veronica Cocetta et al.

Summary: Resistance to chemotherapy remains a challenge in cancer treatment, but resveratrol has shown promise as a chemosensitizer by modulating cancer-related molecular mechanisms. Despite its low bioavailability, efforts are being made to improve drug delivery strategies for more effective use in therapy-refractory cancer patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Therapeutic potentials of resveratrol in combination with radiotherapy and chemotherapy during glioblastoma treatment: a mechanistic review

AmirAhmad Arabzadeh et al.

Summary: Glioblastoma is an aggressive type of brain tumor with resistance to conventional therapies. Resveratrol, a natural polyphenolic compound, has shown to have anti-tumoral effects by regulating various cellular pathways such as cell cycle progression, autophagy, and apoptosis. Studies have also explored the potential of using resveratrol in combination with radiation therapy and chemotherapy for glioblastoma treatment.

CANCER CELL INTERNATIONAL (2021)

Review Immunology

The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review

Sahar Sheikholeslami et al.

Summary: This study reviewed the potential role of alpha-lipoic acid in alleviating radiation-induced toxicities in healthy cells/tissues. Experimental results showed that this radio-protective agent could alleviate radiation-induced toxicities through mechanisms such as anti-oxidant, antiapoptosis, and anti-inflammatory effects. Co-treatment of alpha-lipoic acid with radiotherapy could ameliorate the radiation-induced toxicities in healthy cells/tissues.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Review Cell Biology

A Systematic Review of the Potential Chemoprotective Effects of Resveratrol on Doxorubicin-Induced Cardiotoxicity: Focus on the Antioxidant, Antiapoptotic, and Anti-Inflammatory Activities

Li-Feng Hu et al.

Summary: Resveratrol can alleviate doxorubicin-induced cardiotoxicity by exerting protective effects through mechanisms such as antioxidant, anti-apoptosis, and anti-inflammatory pathways.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Oncology

Increased Reactive Oxygen Species and Distinct Oxidative Damage in Resveratrol-suppressed Glioblastoma Cells

Bin Jia et al.

Summary: The study found that resveratrol's effects on glioblastoma cells are closely related to oxidative stress and mitochondrial function. By activating the ROS-related mitochondrial signal pathway, resveratrol increased ROS production and induced oxidative damage in U251 cells, leading to apoptosis.

JOURNAL OF CANCER (2021)

Review Oncology

Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization

Keywan Mortezaee et al.

CURRENT CANCER DRUG TARGETS (2020)

Review Medicine, Research & Experimental

The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review

Masoud Najafi et al.

LIFE SCIENCES (2020)

Article Pharmacology & Pharmacy

Fluorinated benzylidene indanone exhibits antiproliferative activity through modulation of microtubule dynamics and antiangiogenic activity

Ankita Srivastava et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Review Pharmacology & Pharmacy

Drug delivery systems for resveratrol, a non-flavonoid polyphenol: Emerging evidence in last decades

Zahra Ahmadi et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

Review Pharmacology & Pharmacy

The Protective Mechanism of Cannabidiol in Cardiac Injury: A Systematic Review of Non-Clinical Studies

Mohammad R. H. Shayesteh et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

Review Biochemistry & Molecular Biology

Resveratrol Action on Lipid Metabolism in Cancer

Terezia Kiskova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Medicine, Research & Experimental

Modulation of apoptosis by melatonin for improving cancer treatment efficiency: An updated review

Keywan Mortezaee et al.

LIFE SCIENCES (2019)

Article Biochemistry & Molecular Biology

Alpha-Lipoic Acid Ameliorates Radiation-Induced Lacrimal Gland Injury through NFAT5-Dependent Signaling

Hyuna Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biotechnology & Applied Microbiology

Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer

Yuanyuan Tian et al.

ONCOTARGETS AND THERAPY (2019)

Article Biochemistry & Molecular Biology

Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells

Saeideh Momtaz et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Review Cell Biology

Cyclooxygenase-2 in cancer: A review

Nasser Hashemi Goradel et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Cell Biology

Curcumin as an anti-inflammatory agent: Implications to radiotherapy and chemotherapy

Bagher Farhood et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Pharmacology & Pharmacy

A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy

Qicai Xiao et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Immunology

Role of NFAT5 in the Immune System and Pathogenesis of Autoimmune Diseases

Naeun Lee et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Chemistry, Multidisciplinary

Effect of resveratrol on drug resistance in colon cancer chemotherapy

Lu Huang et al.

RSC ADVANCES (2019)

Review Pharmacology & Pharmacy

The role of melatonin on chemotherapy-induced reproductive toxicity

Hamed Haghi-Aminjan et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2018)

Article Chemistry, Medicinal

Antiproliferative efficacy of curcumin mimics through microtubule destabilization

Sadiya Khwaja et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Cell Biology

Regulation of aging and oxidative stress pathways in aged pancreatic islets using alpha-lipoic acid

Navid Nobakht-Haghighi et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2018)

Article Nutrition & Dietetics

Resveratrol Chemosensitizes TNF-β-Induced Survival of 5-FU-Treated Colorectal Cancer Cells

Constanze Buhrmann et al.

NUTRIENTS (2018)

Review Biochemistry & Molecular Biology

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters

Rasoul Yahyapour et al.

CURRENT MOLECULAR PHARMACOLOGY (2018)

Article Environmental Sciences

The role of minocycline in alleviating aluminum phosphide-induced cardiac hemodynamic and renal toxicity

Hamed Haghi-Aminjan et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

Resveratrol: A Double-Edged Sword in Health Benefits

Bahare Salehi et al.

BIOMEDICINES (2018)

Article Environmental Sciences

Effect of styrene exposure on plasma parameters, molecular mechanisms and gene expression in rat model islet cells

Kamal Niaz et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2017)

Review Biochemistry & Molecular Biology

Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer

Ines Marmol et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

The Role of Resveratrol in Cancer Therapy

Jeong-Hyeon Ko et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Biochemistry & Molecular Biology

Synthesis of pharmacologically important naphthoquinones and anticancer activity of 2-benzyllawsone through DNA topoisomerase-II inhibition

Balagani Sathish Kumar et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2017)

Review Oncology

Metastatic Colorectal Cancer: A Systematic Review of the Value of Current Therapies

Daniel A. Goldstein et al.

CLINICAL COLORECTAL CANCER (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

P9. Correlation of radiation induced apoptosis with Bax and Bcl-2 protein expression

N. Sogwagwa et al.

Physica Medica-European Journal of Medical Physics (2016)

Article Multidisciplinary Sciences

A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells

Elizabeth Thomas et al.

SCIENTIFIC REPORTS (2016)

Review Nutrition & Dietetics

Anticancer Molecular Mechanisms of Resveratrol

Elena M. Varoni et al.

FRONTIERS IN NUTRITION (2016)

Article Pharmacology & Pharmacy

Anticancer activity and toxicity profiles of 2-benzylidene indanone lead molecule

Aastha Singh et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

Article Oncology

Small Molecule Inhibition of MDM2-p53 Interaction Augments Radiation Response in Human Tumors

Lauryn R. Werner et al.

MOLECULAR CANCER THERAPEUTICS (2015)

Article Biochemistry & Molecular Biology

Synthesis of neolignans as microtubule stabilisers

B. Sathish Kumar et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2014)

Article Chemistry, Medicinal

Synthesis of 2-alkoxy and 2-benzyloxy analogues of estradiol as anti-breast cancer agents through microtubule stabilization

B. Sathish Kumar et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

Loss of Urokinase Receptor Sensitizes Cells to DNA Damage and Delays DNA Repair

Pavan B. Narayanaswamy et al.

PLOS ONE (2014)

Article Biochemistry & Molecular Biology

Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin

A. A. Hamid et al.

STEROIDS (2014)

Article Gastroenterology & Hepatology

Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years

Mariusz Panczyk

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Review Biotechnology & Applied Microbiology

Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis

Dinesh Vyas et al.

ONCOTARGETS AND THERAPY (2014)

Article Biochemistry & Molecular Biology

Effects of 5-Fluorouracil on Oxidative Stress and Calcium Levels in the Blood of Patients with Newly Diagnosed Colorectal Cancer

Murat Kocer et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2013)

Article Pharmacology & Pharmacy

Synergistic anti-proliferative effect of resveratrol and etoposide on human hepatocellular and colon cancer cell lines

Fatemehsadat Amiri et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells

Minami Kumazaki et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2013)

Article Pharmacology & Pharmacy

Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1

Zhengguang Wang et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2012)

Review Oncology

The Anticancer Effects of Resveratrol: Modulation of Transcription Factors

Nichelle C. Whitlock et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2012)

Article Cell Biology

Resveratrol Potentiates the Cytotoxic Oxidative Stress Induced by Chemotherapy in Human Colon Cancer Cells

Francisca M. Santandreu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2011)

Review Pharmacology & Pharmacy

Pharmacologic Activation of p53 by Small-Molecule MDM2 Antagonists

Hong Shen et al.

CURRENT PHARMACEUTICAL DESIGN (2011)

Article Nanoscience & Nanotechnology

Therapeutic Potentials of Silver Nanoparticle Complex of alpha-Lipoic Acid

Lakshmy Ramachandran et al.

NANOMATERIALS AND NANOTECHNOLOGY (2011)

Review Biochemistry & Molecular Biology

Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics

Camilla Krakstad et al.

MOLECULAR CANCER (2010)

Article Oncology

Review: Combination therapy in high-risk stage II or stage III colon cancer: current practice and future prospects

Diogo Assed Bastos et al.

Therapeutic Advances in Medical Oncology (2010)

Article Medicine, General & Internal

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

David Moher et al.

ANNALS OF INTERNAL MEDICINE (2009)

Review Biochemistry & Molecular Biology

Resveratrol: Its Biologic Targets and Functional Activity

Shazib Pervaiz et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

Review Biochemistry & Molecular Biology

Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms

Mohammad Athar et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2009)

Article Pharmacology & Pharmacy

Catalase and glutathione peroxidase mimics

Brian J. Day

BIOCHEMICAL PHARMACOLOGY (2009)

Article Integrative & Complementary Medicine

Effects of Combined Chinese Drugs and Chemotherapy in Treating Advanced Non-small Cell Lung Cancer

Chen Yan-zhi et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2009)

Article Agriculture, Multidisciplinary

Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells

M. Emilia Juan et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Resveratrol causes COX-2-and p53-dependent apoptosis in head and neck squamous cell cancer cells

Hung-Yun Lin et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2008)

Review Biochemistry & Molecular Biology

5-fluorouracil: Mechanisms of resistance and reversal strategies

Ning Zhang et al.

MOLECULES (2008)

Article Multidisciplinary Sciences

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling

Jose C. Juarez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Ophthalmology

NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells

Joon H. Lee et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)

Article Biochemistry & Molecular Biology

Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications

C. Alarcn de la Lastral et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2007)

Article Biochemistry & Molecular Biology

Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation

Paloma Bragado et al.

APOPTOSIS (2007)

Article Pharmacology & Pharmacy

Chemopotentiation by PARP inhibitors in cancer therapy

L Tentori et al.

PHARMACOLOGICAL RESEARCH (2005)

Review Oncology

The stats of cancer - New molecular targets come of age

H Yu et al.

NATURE REVIEWS CANCER (2004)

Article Biochemistry & Molecular Biology

5-Fluorouracil suppression of NF-κB is mediated by the inhibition of IκB kinase activity in human salivary gland cancer cells

M Azuma et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

Article Multidisciplinary Sciences

Mammalian MAP kinase signalling cascades

LF Chang et al.

NATURE (2001)

Article Medicine, Research & Experimental

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

PK Epling-Burnette et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

Review Biochemistry & Molecular Biology

STATs in oncogenesis

T Bowman et al.

ONCOGENE (2000)