4.8 Article

Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming

Yao Wang et al.

Summary: The study demonstrates that pre-treatment of CAR T cells with a DNA methyltransferase inhibitor enhances anti-tumor activities, cytokine production, and proliferation, allowing for effective eradication of tumors at low doses and improved response to tumor rechallenge.

NATURE COMMUNICATIONS (2021)

Article Oncology

Shaping Functional Avidity of CAR T Cells: Affinity, Avidity, and Antigen Density That Regulate Response

Raanan Greenman et al.

Summary: This study investigates the functional significance of the biophysical properties of CAR binding by constructing a series of CARs targeting the melanoma tumor-associated antigen Tyr/HLA-A2. The research demonstrates nonmonotonic behaviors of affinity and antigen density, as well as an interrelation between avidity and antigen density, in CAR T cell function.

MOLECULAR CANCER THERAPEUTICS (2021)

Article Multidisciplinary Sciences

T cell circuits that sense antigen density with an ultrasensitive threshold

Rogelio A. Hernandez-Lopez et al.

Summary: The study engineered a two-step positive-feedback circuit that enables human cytotoxic T cells to discriminate targets based on a sigmoidal antigen-density threshold. This circuit involves a low-affinity synthetic Notch receptor controlling the expression of a high-affinity CAR, leading to sharp discrimination between cancer cells and normal cells based on antigen density.

SCIENCE (2021)

Article Hematology

CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity

Tim Sauer et al.

Summary: CD70 is a promising target antigen for AML treatment, and CD70-CAR T cells demonstrate good proliferation and antitumor activity in vitro and in vivo for CD70-positive AML patients, showing potential as a new treatment strategy.

BLOOD (2021)

Article Biochemistry & Molecular Biology

Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma

Jennifer N. Brudno et al.

NATURE MEDICINE (2020)

Article Oncology

Tuning the Antigen Density Requirement for CAR T-cell Activity

Robbie G. Majzner et al.

CANCER DISCOVERY (2020)

Article Medicine, General & Internal

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

Michael Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, Research & Experimental

A rational mouse model to detect on-target, off-tumor CAR T cell toxicity

Mauro Castellarin et al.

JCI INSIGHT (2020)

Article Biotechnology & Applied Microbiology

A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

Angela C. Boroughs et al.

MOLECULAR THERAPY (2020)

Article Multidisciplinary Sciences

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Mohamad Hamieh et al.

NATURE (2019)

Article Oncology

Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence

Sneha Ramakrishna et al.

CLINICAL CANCER RESEARCH (2019)

Article Multidisciplinary Sciences

Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome

Kevin K. Leung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

c-Jun overexpression in CAR T cells induces exhaustion resistance

Rachel C. Lynn et al.

NATURE (2019)

Article Oncology

Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches

Mylinh T. Duong et al.

MOLECULAR THERAPY-ONCOLYTICS (2019)

Article Oncology

CD70, a novel target of CAR T-cell therapy for gliomas

Linchun Jin et al.

NEURO-ONCOLOGY (2018)

Review Biochemistry & Molecular Biology

Structural principles of tumor necrosis factor superfamily signaling

Eva S. Vanamee et al.

SCIENCE SIGNALING (2018)

Review Biochemistry & Molecular Biology

Structural principles of tumor necrosis factor superfamily signaling

Eva S. Vanamee et al.

SCIENCE SIGNALING (2018)

Article Multidisciplinary Sciences

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

Joseph A. Fraietta et al.

NATURE (2018)

Article Oncology

Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers

Qiong J. Wang et al.

CLINICAL CANCER RESEARCH (2017)

Article Immunology

CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia

Carsten Riether et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Multidisciplinary Sciences

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Justin Eyquem et al.

NATURE (2017)

Article Medicine, General & Internal

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

Stephen J. Schuster et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Biochemical Research Methods

Crystal structure of CD27 in complex with a neutralizing noncompeting antibody

Alexey Teplyakov et al.

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Matrix metalloproteinases - From the cleavage data to the prediction tools and beyond

Piotr Cieplak et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

Article Biotechnology & Applied Microbiology

Construction of a linker library with widely controllable flexibility for fusion protein design

Gang Li et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

Article Oncology

DNMT3A mutation leads to leukemic extramedullary infiltration mediated by TWIST1

Jie Xu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2016)

Article Biotechnology & Applied Microbiology

CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia

Challice L. Bonifant et al.

MOLECULAR THERAPY (2016)

Article Biotechnology & Applied Microbiology

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench et al.

NATURE BIOTECHNOLOGY (2016)

Article Immunology

T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs

Matthew A. Burchill et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

Article Biochemistry & Molecular Biology

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long et al.

NATURE MEDICINE (2015)

Article Biochemical Research Methods

The Phyre2 web portal for protein modeling, prediction and analysis

Lawrence A. Kelley et al.

NATURE PROTOCOLS (2015)

Review Medicine, General & Internal

Acute Myeloid Leukemia

Hartmut Doehner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Hematology

How I treat the older patient with acute myeloid leukemia

Gert Ossenkoppele et al.

BLOOD (2015)

Article Biochemistry & Molecular Biology

The Tumor Necrosis Factor Receptor Stalk Regions Define Responsiveness to Soluble versus Membrane-Bound Ligand

Christine Richter et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Biochemical Research Methods

SPICE: Exploration and Analysis of Post-Cytometric Complex Multivariate Datasets

Mario Roederer et al.

CYTOMETRY PART A (2011)

Article Oncology

Kit inhibitor APcK110 extends survival in an AML xenograft mouse model

Stefan Faderl et al.

INVESTIGATIONAL NEW DRUGS (2011)