Tissue residency of memory CD8+ T cells matters in shaping immunogenicity of ovarian cancer

In this issue of Cancer Cell, Anadon et al. perform a multi-omics analysis of ovarian tumor infiltrating tissueresident memory T (TRM) cells at the single-cell level that supports a differentiation model from CD103(-) TCF1(+) re-circulating T-cell precursors driven by tumor antigen recognition. CD103(+) TRM cells play a dominant anti-tumor role in ovarian cancer.

Automated summary

In this study, Anadon et al. conducted a multi-omics analysis on ovarian tumor infiltrating tissue-resident memory T (TRM) cells at the single-cell level. The results provide evidence for a differentiation model from CD103(-) TCF1(+) re-circulating T-cell precursors driven by tumor antigen recognition. CD103(+) TRM cells play a dominant anti-tumor role in ovarian cancer.