Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 198, Issue 3, Pages 415-418Publisher
WILEY
DOI: 10.1111/bjh.18240
Keywords
myelodysplastic syndromes; Hypomethylating agents; lenalidomide
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Funding
- National Health and Medical Research Council
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This study compared the outcomes of adding lenalidomide, valproic acid, or idarubicin to azacitidine in the treatment of patients with higher-risk myelodysplastic syndromes using a randomized 'pick-a-winner' study design.
Hypomethylating agents remain the current standard of care for patients with higher-risk myelodysplastic syndromes. Ades et al. report outcomes from a randomised 'pick-a-winner' study design that examined the addition of either lenalidomide, valproic acid or idarubicin in combination with azacitidine, compared to azacitidine alone. Commentary on: Ades et al. A randomised phase II study of azacitidine (AZA) alone or with lenalidomide (LEN), valproic acid (VPA) or idarubicin (IDA) in higher-risk MDS: GFM's 'pick a winner' trial, with the impact of somatic mutations. Br J Haematol 2022 (Online ahead of print). doi: 10.1111/bjh.18193.
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