Considering therapy-induced senescence as a mechanism of tumour dormancy contributing to disease recurrence

Review Biology

When dormancy fuels tumour relapse

Karla Santos-de-Frutos et al.

Summary: This review article discusses the implication of dormant cancer cells in tumor relapse and the roles that quiescent and senescent cells may play in this process.

COMMUNICATIONS BIOLOGY (2021)

Add to Collection

Editorial Material Oncology

The Quest to Define and Target Cellular Senescence in Cancer

Boshi Wang et al.

Summary: Cellular senescence plays a dual role in cancer and its treatment, with both antimalignant functions and associations with tumor progression and relapse. Combining pro- to antisenescence interventions has shown potential as a new anticancer approach, but targeting therapy-induced senescent cells is challenging due to their heterogeneity. Exploiting senescence-associated features may help improve treatment efficacy and tolerability.

CANCER RESEARCH (2021)

Add to Collection

Article Oncology

Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence

Cihangir Duy et al.

Summary: The study revealed that primary AML cells can enter a senescence-like phenotype after chemotherapy, leading to a decrease in leukemia stem cells and an increase in subpopulations with senescence-like cells. Moreover, ATR inhibitors can transiently impair the persistence of AML cells.

CANCER DISCOVERY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

Christos P. Zampetidis et al.

Summary: Oncogene-induced senescence is an important tumor suppressor mechanism, but if not timely removed, senescent cells may have detrimental effects. We found that replication stress-induced genomic instability may be a causative factor for escape from oncogene-induced senescence.

MOLECULAR CELL (2021)

Add to Collection

Article Multidisciplinary Sciences

Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence

Yao Li et al.

Summary: In an investigation into signaling triggered by aging and hyperglycemia, researchers found that NADPH Oxidase (NOX) plays a crucial role in driving cell damage, inflammation, and cellular senescence. Inhibiting NOX1 can reverse age-related impairments in blood flow and angiogenesis, as well as disrupt proinflammatory signaling associated with senescence. Targeting the NOX1-SASP signaling axis is predicted to be an effective strategy for mitigating vascular and organ system senescence.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Review Oncology

Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

Valerie J. Carpenter et al.

Summary: Senescence is a crucial aspect of tumor cell biology and serves as a primary response to therapy-induced stress. Senolytics, which selectively eliminate senescent cells, are being actively investigated for their potential in cancer treatment. However, there are challenges and unanswered questions in the preclinical literature, prompting the need for further research and evaluation.

CANCERS (2021)

Add to Collection

Article Oncology

Translating the Science of Cancer Dormancy to the Clinic

Julio A. Aguirre-Ghiso

Summary: Understanding cancer dormancy has reshaped the paradigm of metastasis, explaining long remission intervals followed by relapse. While there is consensus on the potential impact of better understanding dormancy, controversy exists on applying this biology to clinical trials. Active clinical trials are resolving these controversies, providing opportunities to target cancer dormancy in reality.

CANCER RESEARCH (2021)

Add to Collection

Review Oncology