Journal
BRITISH JOURNAL OF CANCER
Volume 126, Issue 10, Pages 1363-1365Publisher
SPRINGERNATURE
DOI: 10.1038/s41416-022-01787-6
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Funding
- NIH/NCI [CA 260819, CA 239706]
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Senescence could serve as a pathway to tumour dormancy, and targeting senescent tumour cells with drugs could reduce the risk of recurrence and enhance the efficacy of cancer chemotherapy.
The capability of tumour cells to escape from therapy-induced senescence, as well as cell-non-autonomous functions of senescence, support the premise that senescence could serve as one pathway to tumour dormancy (among others that include quiescence and diapause) that is permissive for disease recurrence. Consequently, the pharmacologic targeting of senescent tumour cells could mitigate the risk for cancer resurgence, thereby enhancing the therapeutic efficacy of cancer chemotherapy.
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