4.5 Letter

Effect of prophylactic or pre-emptive use of tyrosine kinase inhibitors post-Allo SCT in bcr-abl positive acute lymphoblastic leukemia: a subanalysis of GITMO ph-positive ALL study

Related references

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Article Biophysics

Second- and third-generation tyrosine kinase inhibitors for Philadelphia-positive adult acute lymphoblastic leukemia relapsing post allogeneic stem cell transplantation-a registry study on behalf of the EBMT Acute Leukemia Working Party

Klaus Hirschbuehl et al.

Summary: The study evaluated the efficacy of second- and third-generation TKI in 140 patients with Ph + ALL, showing a response rate of 71% and an overall survival rate of 49% at 2 years and 33% at 5 years. TKI were found to be important compounds for managing active Ph + ALL post alloSCT, with comparable toxicity to pretransplant use.

BONE MARROW TRANSPLANTATION (2021)