Related references
Note: Only part of the references are listed.Bisphosphonates in veterinary medicine: The new horizon for use
Larry J. Suva et al.
BONE (2021)
Bisphosphonates for delivering drugs to bone
Shuting Sun et al.
BRITISH JOURNAL OF PHARMACOLOGY (2021)
Clodronate
Eugene McCloskey et al.
BONE (2021)
Bone resorption goes green
Jameel Iqbal et al.
CELL (2021)
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
Michelle M. McDonald et al.
CELL (2021)
Design and Synthesis of Cathepsin-K-Activated Osteoadsorptive Fluorogenic Sentinel (OFS) Probes for Detecting Early Osteoclastic Bone Resorption in a Multiple Myeloma Mouse Model
Eric T. Richard et al.
BIOCONJUGATE CHEMISTRY (2021)
Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
Hayley M. Sabol et al.
CANCER RESEARCH (2021)
A Novel Small Molecule Neurotrophin-3 Analogue Promotes Inner Ear Neurite Outgrowth and Synaptogenesis In vitro
Judith S. Kempfle et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2021)
Farnesoid X receptor (FXR): Structures and ligands
Longying Jiang et al.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)
Targeting Bortezomib to Bone Increases Its Bone Anabolic Activity and Reduces Systemic Adverse Effects in Mice
Hua Wang et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2020)
Pamidronate: A model compound of the pharmacology of nitrogen-containing bisphosphonates; A Leiden historical perspective
Socrates E. Papapoulos
BONE (2020)
Bisphosphonates-much more than only drugs for bone diseases
Anna Kuznik et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2020)
Green one-pot synthesis of N-bisphosphonates as antimicrobial and antioxidant agents
Sreekanth Tellamekala et al.
MONATSHEFTE FUR CHEMIE (2020)
Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation
Yosuke Toyota et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
New applications of squalene synthase inhibitors: Membrane cholesterol as a therapeutic target
Angeliki P. Kourounakis et al.
ARCHIV DER PHARMAZIE (2020)
Bisphosphonates and lifespan
Jacqueline R. Center et al.
BONE (2020)
Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate
Richard Seist et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)
Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton
Michael J. Rogers et al.
BONE (2020)
Targeting anti-cancer agents to bone using bisphosphonates
Lianping Xing et al.
BONE (2020)
Empowering the Medicinal Applications of Bisphosphonates by Unveiling their Synthesis Details
Jessica S. Barbosa et al.
MOLECULES (2020)
Drugs Repurposing Using QSAR, Docking and Molecular Dynamics for Possible Inhibitors of the SARS-CoV-2 Mpro Protease
Eduardo Tejera et al.
MOLECULES (2020)
Completing the β,γ-CXY-dNTP Stereochemical Probe Toolkit: Synthetic Access to the dCTP Diastereomers and 31P and 19F NMR Correlations with Absolute Configurations
Pouya Haratipour et al.
JOURNAL OF ORGANIC CHEMISTRY (2020)
Next Generation Lipophilic Bisphosphonate Shows Antitumor Effect in Colorectal Cancer In Vitro and In Vivo
Marcell Baranyi et al.
PATHOLOGY & ONCOLOGY RESEARCH (2020)
Targeting prenylation inhibition through the mevalonate pathway
Pimyupa Manaswiyoungkul et al.
RSC MEDICINAL CHEMISTRY (2020)
A Study on the Synthesis of Risedronic Acid: The Role of an Ionic liquid Additive
David Illes Nagy et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2019)
Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice
Akishige Hokugo et al.
BONE (2019)
Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response
Yvette Zarb et al.
BRAIN (2019)
Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis
Satish R. Malwal et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
A patent review of bisphosphonates in treating bone disease
Sarah A. Holstein
EXPERT OPINION ON THERAPEUTIC PATENTS (2019)
Bisphosphonate use in the horse: what is good and what is not?
Alexis Mitchell et al.
BMC VETERINARY RESEARCH (2019)
α-Heteroatom-substituted gem-Bisphosphonates: Advances in the Synthesis Prospects for Biomedical Application
Vadim D. Romanenko
CURRENT ORGANIC CHEMISTRY (2019)
Phosphonate prodrugs: an overview and recent advances
Kenneth M. Heidel et al.
FUTURE MEDICINAL CHEMISTRY (2019)
Metal Coordination Is Crucial for Geranylgeranyl Diphosphate Synthase-Bisphosphonate Interactions: A Crystallographic and Computational Analysis
Michal Lisnyansky et al.
MOLECULAR PHARMACOLOGY (2019)
Increased flux through the mevalonate pathway mediates fibrotic repair without injury
Jennifer L. Larson-Casey et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
rGO-SO3H Catalysed Green Synthesis of Fluoro-Substituted Aminomethylene Bisphosphonates and their Anti-cancer, Molecular Docking studies
Murali Sudileti et al.
CHEMISTRYSELECT (2019)
Pharmacology of bisphosphonates
Serge Cremers et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2019)
Diketopyrrolopyrrole Bis-Phosphonate Conjugate: A New Fluorescent Probe for In Vitro Bone Imaging
Andrea Chiminazzo et al.
CHEMISTRY-A EUROPEAN JOURNAL (2019)
Zoledronic acid promotes TLR-4-mediated M1 macrophage polarization in bisphosphonate-related osteonecrosis of the jaw
Weiwen Zhu et al.
FASEB JOURNAL (2019)
First-in-Human Phase I Study of MBC-11, a Novel Bone-Targeted Cytarabine-Etidronate Conjugate in Patients with Cancer-Induced Bone Disease
Shawn Patrick Zinnen et al.
ONCOLOGIST (2019)
Zoledronic Acid-containing Nanoparticles With Minimum Premature Release Show Enhanced Activity Against Extraskeletal Tumor
Xu Li et al.
ACS APPLIED MATERIALS & INTERFACES (2019)
α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors
Robert A. Matthiesen et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2018)
Targeting therapeutics to bone by conjugation with bisphosphonates
Robert N. Young et al.
CURRENT OPINION IN PHARMACOLOGY (2018)
Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors
Cyrus M. Lacbay et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Efficient Synthesis of Ibandronate in the Presence of an Ionic Liquid
David Illes Nagy et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2018)
CuI-Catalyzed [3+2] Cycloaddition of Hindered Vinylidenebisphosphonates (VBP) with Azomethine Imines for Highly Regioselective Access to Dinitrogen-Heterobicycle-Containing Bisphosphonates
Zhongxiang Zhu et al.
SYNTHESIS-STUTTGART (2018)
Efficient syntheses of zoledronic acid as an active ingredient of a drug against osteoporosis
David Illes Nagy et al.
SYNTHETIC COMMUNICATIONS (2018)
Rh(III)-Catalyzed directed C-H carbenoid coupling reveals aromatic bisphosphonates inhibiting metallo- and Serine-beta-lactamases
Chen Zhang et al.
ORGANIC CHEMISTRY FRONTIERS (2018)
Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone-Relevant Cell Types
Neus Roca-Ayats et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2018)
Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice
Hua Wang et al.
PHARMACEUTICS (2018)
Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures
Michal Lisnyansky et al.
MOLECULAR PHARMACOLOGY (2018)
Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis
Jacqueline E. Reilly et al.
CANCER BIOLOGY & THERAPY (2017)
In vivo distribution of zoledronic acid in a bisphosphonate-metal complex-based nanoparticle formulation synthesized by a reverse microemulsion method
Xu Li et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)
Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis
Karen L. de Mesy Bentley et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2017)
The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate)
Michelle A. Lawson et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2017)
Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms
Parish P. Sedghizadeh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Nano ZnO catalyzed green synthesis and cytotoxic assay of pyridinyl and pyrimidinyl bisphosphonates
Gundluru Mohan et al.
MONATSHEFTE FUR CHEMIE (2017)
Bad to the Bone: On In Vitro and Ex Vivo Microbial Biofilm Ability to Directly Destroy Colonized Bone Surfaces without Participation of Host Immunity or Osteoclastogenesis
Adam Junka et al.
PLOS ONE (2017)
Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase
Jaeok Park et al.
PLOS ONE (2017)
Teriparatide attenuates scarring around murine cranial bone allograft via modulation of angiogenesis
Doron Cohn Yakubovich et al.
BONE (2017)
Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine
Shuting Sun et al.
BIOCONJUGATE CHEMISTRY (2016)
Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their Function
Juhi Misra et al.
STEM CELLS (2016)
Targeted delivery to bone and mineral deposits using bisphosphonate ligands
Lisa E. Cole et al.
ADVANCED DRUG DELIVERY REVIEWS (2016)
Microwave-assisted synthesis of (aminomethylene) bisphosphine oxides and (aminomethylene) bisphosphonates by a three-component condensation
Erika Balint et al.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2016)
Developments in the synthesis of new functionalized bisphosphonate drug candidates such as cyclic prodrugs
V. A. Pavlov et al.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS (2016)
In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates
Gyongseon Yang et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
Maria K. Tsoumpra et al.
BONE (2015)
Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis
Heather L. Osborn-Heaford et al.
FREE RADICAL BIOLOGY AND MEDICINE (2015)
Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase
Takeshi Yokoyama et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
The Synthesis of Risedronic Acid and Alendronate Applying Phosphorus Oxychloride and Phosphorous Acid in Methanesulfonic Acid
Alajos Gruen et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2015)
Non-Ototoxic Local Delivery of Bisphosphonate to the Mammalian Cochlea
Woo Seok Kang et al.
OTOLOGY & NEUROTOLOGY (2015)
Endocytotic Uptake of Zoledronic Acid by Tubular Cells May Explain Its Renal Effects in Cancer Patients Receiving High Doses of the Compound
Anja Verhulst et al.
PLOS ONE (2015)
One-Pot, Highly Regioselective 1,3-Dipole Cycloaddition Promoted by Montmorillonite for the Synthesis of Spiro[indole-pyrrolizine], Spiro[indole-indolizine], and Spiro[indole-pyrrolidine] gem-Bisphosphonates
Guozhu Li et al.
SYNTHESIS-STUTTGART (2015)
Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase
Veronica S. Wills et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo; Role in osteoclast-mediated NK cell activation
Han-Ching Tseng et al.
ONCOTARGET (2015)
Prenylation Inhibition-Induced Cell Death in Melanoma: Reduced Sensitivity in BRAF Mutant/PTEN Wild-Type Melanoma Cells
Tamas Garay et al.
PLOS ONE (2015)
Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Simon Junankar et al.
CANCER DISCOVERY (2015)
Synthesis of isoprenoid bisphosphonate ethers through C-P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase
Xiang Zhou et al.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2014)
Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase
Xiang Zhou et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Synthesis of Nucleoside Phosphate and Phosphonate Prodrugs
Ugo Pradere et al.
CHEMICAL REVIEWS (2014)
The effect of bisphosphonates on the risk of endometrial and ovarian malignancies
Gad Rennert et al.
GYNECOLOGIC ONCOLOGY (2014)
Development of oral osteomucosal tissue constructs in vitro and localization of fluorescently-labeled bisphosphonates to hard and soft tissue
Susan Bae et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2014)
Bisphosphonate Uptake in Areas of Tooth Extraction or Periapical Disease
Simon Cheong et al.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2014)
A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin
Yifeng Xia et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Squalene Synthase As a Target for Chagas Disease Therapeutics
Na Shang et al.
PLOS PATHOGENS (2014)
Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates
Srinivas Aripirala et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2014)
Greener synthesis of bisphosphonic/dronic acid derivatives
Rita Kovacs et al.
GREEN PROCESSING AND SYNTHESIS (2014)
Triazole-based inhibitors of geranylgeranyltransferase II
Xiang Zhou et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Jaw bone marrow-derived osteoclast precursors internalize more bisphosphonate than long-bone marrow precursors
Jenny A. F. Vermeer et al.
BONE (2013)
Equilibrium-dependent bisphosphonate interaction with crystalline bone mineral explains anti-resorptive pharmacokinetics and prevalence of osteonecrosis of the jaw in rats
Akishige Hokugo et al.
BONE (2013)
Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition
Chun Yuen Leung et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Optimized Synthesis of Etidronate
Rita Kovacs et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2013)
Microwave-assisted efficient synthesis of bisphosphonate libraries: a useful procedure for the preparation of bisphosphonates containing nitrogen and sulfur
Racha Lenin et al.
MEDICINAL CHEMISTRY RESEARCH (2013)
Bisphosphonate Binding Affinity Affects Drug Distribution in Both Intracortical and Trabecular Bone of Rabbits
John Turek et al.
CALCIFIED TISSUE INTERNATIONAL (2012)
Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth
Gatien Moriceau et al.
CANCER (2012)
Influence of Bone Affinity on the Skeletal Distribution of Fluorescently Labeled Bisphosphonates In Vivo
Anke J. Roelofs et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2012)
Efficacy and safety of a novel delayed-release risedronate 35 mg once-a-week tablet
M. R. McClung et al.
OSTEOPOROSIS INTERNATIONAL (2012)
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity
Joo Hwan No et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The relationship between the chemistry and biological activity of the bisphosphonates
Frank H. Ebetino et al.
BONE (2011)
Bisphosphonates: The first 40 years
R. Graham G. Russell
BONE (2011)
Synthesis and bio-activity evaluation of tetraphenyl(phenylamino) methylene bisphosphonates as antioxidant agents and as potent inhibitors of osteoclasts in vitro
A. Balakrishna et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors
Katarzyna M. Blazewska et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
A One-Pot Synthesis of 1-Hydroxy-1,1-bis(phosphonic acid)s Starting from the Corresponding Carboxylic Acids
Maxim Egorov et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2011)
Bisphosphonamidate Clodronate Prodrug Exhibits Potent Anticancer Activity in Non-Small-Cell Lung Cancer Cells
Marie R. Webster et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Remarkable Potential of the α-Aminophosphonate/Phosphinate Structural Motif in Medicinal Chemistry
Artur Mucha et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
α-Azido Bisphosphonates: Synthesis and Nucleotide Analogues
Brian T. Chamberlain et al.
JOURNAL OF ORGANIC CHEMISTRY (2011)
Optimized synthesis of N-heterocyclic dronic acids; closing a black-box era
Gyoergy Keglevich et al.
TETRAHEDRON LETTERS (2011)
Microwave-assisted synthesis of nitrogen-containing 1-hydroxymethylenebisphosphonate drugs
Dana A. Mustafa et al.
TETRAHEDRON LETTERS (2011)
Design, synthesis, and biological evaluation of novel estradiol-bisphosphonate conjugates as bone-specific estrogens
Masahiko Morioka et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Synthesis and in vitro evaluation of bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis
Kelly S. E. Tanaka et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Fluorescent Risedronate Analogues Reveal Bisphosphonate Uptake by Bone Marrow Monocytes and Localization Around Osteocytes In Vivo
Anke J. Roelofs et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2010)
Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase
Rudi A. Baron et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation
Yonghui Zhang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Fluorescently Labeled Risedronate and Related Analogues: Magic Linker Synthesis
Boris A. Kashemirov et al.
BIOCONJUGATE CHEMISTRY (2008)
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: A crystallographic and computational investigation
Cammy K. -M. Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Linking Bisphosphonates to the Free Amino Groups in Fluoroquinolones: Preparation of Osteotropic Prodrugs for the Prevention of Osteomyelitis
Tom J. Houghton et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
R. G. G. Russell et al.
OSTEOPOROSIS INTERNATIONAL (2008)
Click chemistry, a powerful tool for pharmaceutical sciences
Christopher D. Hein et al.
PHARMACEUTICAL RESEARCH (2008)
Synthesis and biological evaluation of α-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate
Mong S. Marma et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Anke J. Roelofs et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Apomine™, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo
Claire M. Edwards et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Cytotoxic activity of Apomine is due to a novel membrane-mediated cytolytic mechanism independent of apoptosis in the A375 human melanoma cell line
Alan Pourpak et al.
INVESTIGATIONAL NEW DRUGS (2007)
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase
Andrew J. Wiemer et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
'Magic bullets' for bone diseases: progress in rational design of bone-seeking medicinal agents
Sufeng Zhang et al.
CHEMICAL SOCIETY REVIEWS (2007)
Synthesis and biological activity of isoprenoid bisphosphonates
Larry W. Shull et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
A phase II open-label trial of apomine (SR-45023A) in patients with refractory melanoma
KD Lewis et al.
INVESTIGATIONAL NEW DRUGS (2006)
Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
FH Ebetino et al.
JOURNAL OF ORGANOMETALLIC CHEMISTRY (2005)
Copper-mediated displacements of allylic THP ethers on a bisphosphonate template
LW Shull et al.
JOURNAL OF ORGANOMETALLIC CHEMISTRY (2005)
Induction of apoptosis in breast cancer cells by apomine is mediated by caspase and p38 mitogen activated protein kinase activation
LC Lowe et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity
J Roitelman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Population pharmacokinetics of APOMINE™:: A meta-analysis in cancer patients and healthy males
PL Bonate et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2004)
Bisphosphonate prodrugs
JJ Vepsäläinen
CURRENT MEDICINAL CHEMISTRY (2002)
Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages
FP Coxon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The nuclear receptors FXR and LXRα:: Potential targets for the development of drugs affecting lipid metabolism and neoplastic diseases
EJ Niesor et al.
CURRENT PHARMACEUTICAL DESIGN (2001)
A peptide prodrug approach for improving bisphosphonate oral absorption
A Ezra et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol
J Flach et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)