The efficacy and safety of Iodine-131-metaiodobenzylguanidine therapy in patients with neuroblastoma: a meta-analysis

Objective Neuroblastoma is a common extracranial solid tumor of childhood. Recently, multiple treatments have been practiced including Iodine-131-metaiodobenzylguanidine radiation (I-131-MIBG) therapy. However, the outcomes of efficacy and safety vary greatly among different studies. The aim of this meta-analysis is to evaluate the efficacy and safety of I-131-MIBG in the treatment of neuroblastoma and to provide evidence and hints for clinical decision-making. Methods Medline, EMBASE database and the Cochrane Library were searched for relevant studies. Eligible studies utilizing I-131-MIBG in the treatment of neuroblastoma were included. The pooled outcomes (response rates, adverse events rates, survival rates) were calculated using either a random-effects model or a fixed-effects model considering of the heterogeneity. Results A total of 26 clinical trials including 883 patients were analyzed. The pooled rates of objective response, stable disease, progressive disease, and minor response of I-131-MIBG monotherapy were 39%, 31%, 22% and 15%, respectively. The pooled objective response rate of I-131-MIBG in combination with other therapies was 28%. The pooled 1-year survival and 5-year survival rates were 64% and 32%. The pooled occurrence rates of thrombocytopenia and neutropenia in MIBG monotherapy studies were 53% and 58%. In the studies of I-131-MIBG combined with other therapies, the pooled occurrence rates of thrombocytopenia and neutropenia were 79% and 78%. Conclusion I-131-MIBG treatment alone or in combination of other therapies is effective on clinical outcomes in the treatment of neuroblastoma, individualized I-131-MIBG is recommended on a clinical basis.

Automated summary

This meta-analysis evaluated the efficacy and safety of I-131-MIBG in the treatment of neuroblastoma. Overall, I-131-MIBG monotherapy and combination therapy showed effectiveness in clinical outcomes. However, there were significant variations in safety outcomes among different studies.