With age comes resilience

In this issue of Blood, Farley et al(1) use a mouse model of fetal and neonatal alloimmune thrombocytopenia (FNAIT) to show how risk of intracranial hemorrhage (ICH) varies with platelet count and developmental age. In addition to delineating critical platelet thresholds, they demonstrate that mice develop resilience to thrombocytopenia-associated ICH shortly after birth.

Automated summary

This study investigates the impact of fetal and neonatal alloimmune thrombocytopenia on the risk of intracranial hemorrhage using a mouse model. The authors not only identify critical platelet thresholds but also demonstrate the development of resilience to thrombocytopenia-associated intracranial hemorrhage in mice shortly after birth.