Firing up chromatin to forge T-ALL

In this issue of Blood, Antoszewski et al report that the transcription factor T-cell factor 1 (Tcf1) remodels chromatin in Notch-activated early hematopoietic progenitor cells to promote transformation through oncogenes like MYC.(1)

Automated summary

In this study, Antoszewski et al find that the transcription factor T-cell factor 1 (Tcf1) remodels chromatin in early hematopoietic progenitor cells activated by Notch, thereby promoting transformation into cancer cells.