4.7 Article

Risk assessment with low-pass whole-genome sequencing of cell-free DNA before CD19 CAR T-cell therapy for large B-cell lymphoma

Related references

Note: Only part of the references are listed.
Article Oncology

Single-Agent Mosunetuzumab Shows Durable Complete Responses in Patients With Relapsed or Refractory B-Cell Lymphomas: Phase I Dose-Escalation Study

Lihua E. Budde et al.

Summary: This study evaluated the safety, tolerability, and efficacy of mosunetuzumab in patients with relapsed or refractory B-cell non-Hodgkin lymphomas (B-NHLs). The results showed that mosunetuzumab has a manageable safety profile and induces durable complete responses in some patients.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Oncology

Impact of TP53 Genomic Alterations in Large B-Cell Lymphoma Treated With CD19-Chimeric Antigen Receptor T-Cell Therapy

Roni Shouval et al.

Summary: TP53 mutations/CNAs are important determinants of response and survival in LBCL patients treated with CD19-CAR-T therapy. TP53 alterations are associated with poor treatment outcomes and lower survival rates.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Hematology

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma

Man Chun John Ma et al.

Summary: This study comprehensively analyzed the genomic landscapes of multiple B-cell non-Hodgkin lymphoma (B-NHL) subtypes, and identified common features and subtype-specific patterns of genetic alterations. The study also revealed potential patterns of genetic cooperation that contribute to lymphomagenesis, providing important insights into the pathogenesis of B-NHL.

HAEMATOLOGICA (2022)

Review Oncology

Circulating Tumor DNA in Lymphoma: Principles and Future Directions

Mark Roschewski et al.

Summary: Lymphomas are heterogeneous tumors with variable outcomes. Current treatment response assessment methods cannot detect disease at the molecular level, and molecular tumor analyses cannot accurately capture spatial tumor heterogeneity. Circulating tumor DNA (ctDNA) is a minimally invasive biomarker that overcomes limitations of imaging scans and tissue biopsies, aiding clinical decision-making in lymphoma.

BLOOD CANCER DISCOVERY (2022)

Article Oncology

A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy

Ranjan Upadhyay et al.

Summary: The study revealed the crucial role of Fas-FasL in T cell killing of tumors and the bystander killing of antigen-negative tumor cells. This new finding may enhance the efficacy of immunotherapies and prevent cancer relapse by targeting both antigen expression and antigen-loss variants.

CANCER DISCOVERY (2021)

Article Oncology

Loncastuximab tesirine in relapsed or refractory diffuse large B-cell lymphoma (LOTIS-2): a multicentre, open-label, single-arm, phase 2 trial

Paolo F. Caimi et al.

Summary: Loncastuximab tesirine shows substantial antitumor activity and acceptable safety profile in patients with relapsed or refractory DLBCL, potentially offering a new therapeutic option for heavily pretreated individuals.

LANCET ONCOLOGY (2021)

Article Oncology

Monitoring of Circulating Tumor DNA Improves Early Relapse Detection After Axicabtagene Ciloleucel Infusion in Large B-Cell Lymphoma: Results of a Prospective Multi-Institutional Trial

Matthew J. Frank et al.

Summary: This study demonstrated the prognostic value of circulating tumor DNA (ctDNA) in predicting outcomes of large B-cell lymphoma patients undergoing axicabtagene ciloleucel (axi-cel) treatment. Higher baseline ctDNA concentrations were associated with progression post-treatment and development of toxicities. Additionally, patients with undetectable ctDNA 1 week after axi-cel infusion had higher rates of durable response compared to those with detectable ctDNA.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Long-term clinical outcomes of tisagenlecleucel in patients with relapsed or refractory aggressive B-cell lymphomas (JULIET): a multicentre, open-label, single-arm, phase 2 study

Stephen J. Schuster et al.

Summary: The JULIET trial evaluated the long-term treatment outcomes and safety of tisagenlecleucel in adult patients, showing durable activity and manageable safety profiles in patients with relapsed or refractory aggressive B-cell lymphomas. Tisagenlecleucel compared favorably with conventional therapeutic approaches for patients with large B-cell lymphomas that are refractory to chemoimmunotherapy or relapsing after second-line therapies.

LANCET ONCOLOGY (2021)

Article Oncology

Polatuzumab Vedotin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Laurie H. Sehn et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Medicine, General & Internal

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Stephen J. Schuster et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Multidisciplinary Sciences

Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma

S. Manier et al.

NATURE COMMUNICATIONS (2018)

Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Multidisciplinary Sciences

Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

Viktor A. Adalsteinsson et al.

NATURE COMMUNICATIONS (2017)

Article Biotechnology & Applied Microbiology

CopywriteR: DNA copy number detection from off-target sequence data

Thomas Kuilman et al.

GENOME BIOLOGY (2015)

Article Multidisciplinary Sciences

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

Rameen Beroukhim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)