GATA1: function through disorder

In this issue of Blood, Ludwig et al characterize a rare form of inherited hemolytic anemia. They identified novel mutations in an intrinsically disordered region (IDR) in the GATA1 carboxyl (C)-terminal domain, which underlie novel functions in selectively regulating GATA1 chromatin occupancies in erythropoiesis.(1)

Automated summary

In this article, Ludwig et al characterize a rare form of inherited hemolytic anemia and identify novel mutations in an intrinsically disordered region (IDR) in the GATA1 carboxyl (C)-terminal domain. These mutations have novel functions in selectively regulating GATA1 chromatin occupancies in erythropoiesis.