Targeting vulnerabilities of adult T-cell leukemia

In this issue of Blood, Ishio et al(1) identified the genes critical for proliferation and/or survival of adult T-cell leukemia-lymphoma (ATL) cells using wholegenome CRISPR library screening. They also discovered that the mTORC1 pathway is critical for ATL cells.

Automated summary

In this study, Ishio et al identified the crucial genes and the importance of the mTORC1 pathway in the proliferation and survival of adult T-cell leukemia-lymphoma (ATL) cells using whole-genome CRISPR library screening.