Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 72, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2022.128823
Keywords
HBV; Capsid; Diazepinone
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The HBV capsid core protein plays crucial roles in the viral life cycle and is a potential drug target for treating chronic HBV infection. The optimization of diazepinone HBV CAMs, which interfere with capsid assembly, is described in this study.
The HBV capsid core protein serves a number of important functions in the viral life cycle enabling chronic HBV infection to persist, and therefore is a promising drug target. Interfering with capsid assembly has shown efficacy in clinical trials with small molecule capsid assembly modulators (CAMs). Herein is described the further opti-mization of a progressive series of diazepinone HBV CAMs.
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