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PARASITOLOGY INTERNATIONAL (2006)
Structural differences in triosephosphate isomerase from different species and discovery of a multitrypanosomatid inhibitor
V Olivares-Illana et al.
BIOCHEMISTRY (2006)
Cyp51 from Trypanosoma cruzi -: A phyla-specific residue in the B′ helix defines substrate preferences of sterol 14α-demethylase
GI Lepesheva et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor
N Schormann et al.
JOURNAL OF STRUCTURAL BIOLOGY (2005)
Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate
DK Inaoka et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2005)
The protein farnesyltransferase inhibitor tipifarnib as a new lead for the development of drugs against Chagas disease
O Hucke et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Lipophilic antifolate trimetrexate is a potent inhibitor of Trypanosoma cruzi:: Prospect for chemotherapy of Chagas' disease
O Senkovich et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase
S Khabnadideh et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Structural considerations for the rational design of selective anti-trypanosomal agents: The role of the aromatic clusters at the interface of triosephosphate isomerase dimer
LM Espinoza-Fonseca et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells
T Nara et al.
PARASITOLOGY INTERNATIONAL (2005)
The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions
T Annoura et al.
JOURNAL OF MOLECULAR EVOLUTION (2005)
A molecular modeling and QSAR study of suppressors of the growth of Trypanosoma cruzi epimastigotes
CHTD da Silva et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2004)
Inactivation of triosephosphate isomerase from Trypanosoma cruzi by an agent that perturbs its dimer interface
A Téllez-Valencia et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Exploring the possible binding sites at the interface of triosephosphate isomerase dimer as a potential target for anti-tripanosomal drug design
LM Espinoza-Fonseca et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
2,4-diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase
D Pez et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Highly specific inactivation of triosephosphate isomerase from Trypanosoma cruzi
A Téllez-Valencia et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi
E Takashima et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2002)
Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase
SF Chowdhury et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2002)
Expression, purification, crystallization and preliminary crystallographic analysis of recombinant pteridine reductase of Trypanosoma cruzi
N Schormann et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2001)
Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites
DG Gourley et al.
NATURE STRUCTURAL BIOLOGY (2001)
Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase
F Zuccotto et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2001)
A target within the target:: probing Cruzain's P1′ site to define structural determinants for the Chagas' disease protease
LS Brinen et al.
STRUCTURE WITH FOLDING & DESIGN (2000)
Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines
MOF Khan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)