Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 148, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.112752
Keywords
Reproduction; Exosomes; Cell; Functions; Reproductive system
Funding
- statutory found of the Department of Environmental Hygiene and Animal Welfare, Wroclaw University of Environmental and Life Sciences (Poland)
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Exosomes, nano-sized structures found in reproductive fluids, can influence processes in the male and female reproductive systems and serve as biomarkers for diseases, aiding in the diagnosis of genital dysfunction and fertility disorders.
Exosomes are nano-sized structures that are found in semen, epididymal -fluid, endometrium, as well as in follicular fluid. They are responsible for transporting bioactive cargo-proteins, lipids, and nucleic acids. Exosomes have been proven to influence processes in both female and male reproductive systems, including gametogenesis, acrosomal reaction, sperm capacitation, and embryo implantation in the endometrium. Exosomes are made of the same particles as the cells they come from and are secreted by normal and pathological cells. Therefore, exosomes can reflect the physiological state of cells. Moreover, due to the transportation of biomolecules, they participate in intercellular communication and can be used as biomarkers of many diseases, including ovarian, endometrial and prostate cancer. Identification of exosomes as biomarkers could contribute to a better understanding of genital dysfunction and fertility disorders.
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