Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 150, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.113011
Keywords
Genome editing; Cancer; CRISPR/Cas9; TALEN; Molecular mechanisms
Funding
- Deanship of Scientific Research (DSR) at King Khalid University in Abha, Saudi Arabia [RGP: 2/52/1443]
Ask authors/readers for more resources
Cancer is a common and deadly disease worldwide, with metastasis being the main cause. Gene editing techniques can help discover new drug targets and study the molecular mechanisms of cancer. Among these techniques, CRISPR/Cas9 stands out for its high efficiency and precision. Its applications in cancer research contribute to improving cancer treatment and overcoming current challenges.
Cancer accounted for almost ten million deaths worldwide in 2020. Metastasis, characterized by cancer cell invasion to other parts of the body, is the main cause of cancer morbidity and mortality. Therefore, understanding the molecular mechanisms of tumor formation and discovery of potential drug targets are of great importance. Gene editing techniques can be used to find novel drug targets and study molecular mechanisms. In this review, we describe how popular gene-editing methods such as CRISPR/Cas9, TALEN and ZFNs work, and, by comparing them, we demonstrate that CRISPR/Cas9 has superior efficiency and precision. We further provide an overview of the recent applications of CRISPR/Cas9 to cancer research, focusing on the most common cancers such as breast cancer, lung cancer, colorectal cancer, and prostate cancer. We describe how these applications will shape future research and treatment of cancer, and propose new ways to overcome current challenges.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available