Extraction, structure, and activity of polysaccharide from Radix astragali

Radix astragali polysaccharide (RAP) is a water-soluble heteropolysaccharide. It is an immune promoter and regulator, and has antivirus, antitumor, anti-aging, anti-radiation, anti-stress, anti-oxidation and other activitys. The extraction, separation, purification, structure, activity and modification of RAP were summarized. Some extraction methods of RAP had been introduced, and the separation and purification methods of RAP were reviewed, and the structure and activity of RAP were highly discussed. Current derivatization of RAP was outlined. Through the above discussion that the yield of crude polysaccharides from Radix astragali by enzyme-assisted extraction was significantly higher than that by other extraction methods, but each extraction method had different extraction effects under certain conditions, and the activity efficiency of RAP was also different. Therefore, it is particularly important to optimize the extraction method with known better yield for the study of RAP. In addition, the purification and separation of RAP are the key factors affecting the yield and activity of RAP. At the same time, there are still few studies on the derivatiration of Radix astragali polysaccharide, but the researches in this area are very important. RAP also has many important pharmacological effects on human body, but its practical application needs further study. Finally, studies on the structure-activity relationship of RAP still need to be carried out by many scholars. This review would provide some help for further researches on various important applications of RAP.

Automated summary

This article summarizes the extraction, separation, purification, structure, activity, and modification of Radix astragali polysaccharide (RAP). Enzyme-assisted extraction has been found to have a significantly higher yield than other extraction methods, but the extraction effects and activity efficiency of RAP vary under different conditions. The purification and separation of RAP are crucial factors affecting its yield and activity. Current research on the derivatization of RAP is limited but important. Additionally, further studies on the structure-activity relationship of RAP are needed. Overall, this review provides useful insights for future research on the various important applications of RAP.