Journal
IUBMB LIFE
Volume 68, Issue 11, Pages 904-907Publisher
WILEY-BLACKWELL
DOI: 10.1002/iub.1561
Keywords
periplasmic space; protein quality control; outer membrane protein biogenesis
Categories
Funding
- National Basic Research Program of China (973 Program) [2012CB917300]
- National Natural Science Foundation of China [31170738, 31470766]
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The DegP (or HtrA) is a highly conserved family of proteins functioning in all living organisms. It was initially identified as a protease functioning in the periplasmic space of the Gram-negative bacterial cells. It was later reported to also exhibit chaperone activity and thus has been designated as a bifunctional protein. However, recent studies demonstrated that in living cells it more likely functions only as a protease with hardly detectable chaperone activities. In this review, I will summarize the evidences clarifying that DegP more likely only functions as a protease rather than as a chaperone in cells. (C) 2016 IUBMB Life
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