Journal
BIOMATERIALS
Volume 282, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2022.121381
Keywords
Raman imaging; DNA assembly; SERS; Uniform intra-tumor distribution; Photothermal therapy
Funding
- National Key Research and Development Program of China [2020YFA0210800]
- National Natural Science Foundation of China [21874092, 52161160307, 31671003]
- Startup Fund for Young Faculty at Shanghai Jiao Tong University [21X010501069]
- Science and Technology Commission of Shanghai Municipality [19ZR1428800]
- Innovative Research Team of High-Level Local Universities in Shanghai
- Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases
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This study presents a DNA-assembled nanomaterial that achieves uniform distribution of photothermal agents in tumor tissues, enhancing photothermal therapy efficiency. By utilizing the explosive dissociation of hydrogen bonds, the large-sized nanomaterial is broken down into smaller photothermal agents, promoting their diffusion and improving their anti-tumor effects.
Photothermal therapy (PTT) has received increasing attention for treating tumors. However, a long-standing challenge in PTT is non-uniform distribution of photothermal agents (PAs) in tumor tissues, resulting in limited therapeutic efficiency. Herein, inspired by dandelions blowing away by the wind, we have designed a DNA-assembled visible GRS-DNA-CuS nanodandelion, which can achieve uniform intra-tumor distribution (UITD) of PAs, thus enhancing the photothermal therapeutic efficiency. GRS-DNA-CuS is featured by the formation of hydrogen bond between the core of single-strand DNA-modified Raman nanoprobes (GRS) and the shell of complementary single-strand DNA-modified CuS PAs. Under Raman imaging-guided 1st NIR irradiation, hydrogen bond in GRS-DNA-CuS is explosively broken, resulting in large-sized GRS-DNA-CuS (similar to 135 nm) be completely dissociated into GRS and ultra-small CuS PAs (similar to 12 nm) within 1 min. Such an explosive dissociation instantly enhances the local concentration of ultra-small CuS PAs and slightly rises intra-tumor temperature, thus increasing the diffusion coefficient of PAs and promoting their UITD. This UITD of CuS PAs enhances the photothermal anti-tumor effects. Three out of five tumors are completely eliminated under photoacoustic imaging-guided 2nd NIR irradiation. Overall, this study provides one UITD-guided PTT strategy for highly effective tumor treatment by exerting explosive breakage property of hydrogen bond, broadening the application scope of DNA-assembly technique in oncology field.
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